Immunological investigations · 2012
Diversity of HLA-B*35 alleles and haplotypes among Croatians.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Calusic Marija, Grubic Zorana, Stingl Katarina, Kamenaric Marija Burek, Zunec Renata
Аннотация
OBJECTIVES: Investigation of HLA-B*35 subtypes and haplotypes among Croatians.
METHODS: 4000 randomly selected unrelated donors from Croatian Bone Marrow Donor Registry were typed for HLA-A, -B and -DRB1 by PCR-LabType®SSO method.
RESULTS: Four different B*35 alleles (*35:01, *35:02, *35:03, *35:08) were found. Three of them were with similar frequencies as in other European Caucasians, while HLA-B*35:03 was two times more frequent in our population. Predicted haplotypes were also in accordance with present data from other populations.
CONCLUSIONS: This study should be of benefit in the unrelated haematopoietic stem cell transplantation (HSCT) program. It should facilitate the recipient-donor matching and the selection of a suitable population for further searches.
METHODS: 4000 randomly selected unrelated donors from Croatian Bone Marrow Donor Registry were typed for HLA-A, -B and -DRB1 by PCR-LabType®SSO method.
RESULTS: Four different B*35 alleles (*35:01, *35:02, *35:03, *35:08) were found. Three of them were with similar frequencies as in other European Caucasians, while HLA-B*35:03 was two times more frequent in our population. Predicted haplotypes were also in accordance with present data from other populations.
CONCLUSIONS: This study should be of benefit in the unrelated haematopoietic stem cell transplantation (HSCT) program. It should facilitate the recipient-donor matching and the selection of a suitable population for further searches.