HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102.

The new human leukocyte antigen-DQB1*0319 allele was identified in a prospective bone marrow donor by sequence-based typing. This novel allele differs from the DQB1*0301 allele at nucleotide position 554 (C-->T), which results in a Thr to Ile amino acid exchange. The new allele shows a strong association to DRB1*1102, suggesting that the haplotype DRB1*1102-DQB1*0319 is quite common.