JAMA · 2004
Endometrial cells derived from donor stem cells in bone marrow transplant recipients.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Taylor Hugh S
Аннотация
CONTEXT: Regeneration of the endometrium in each menstrual cycle is required for reproduction. Endogenous endometrial stem cells reside in the basalis layer and serve as a source of cells that differentiate to form the endometrium. Bone marrow-derived cells have been shown to take on functions outside the hematopoietic system.
OBJECTIVE: To investigate the possibility that cells of extrauterine origin could repopulate the endometrium.
DESIGN, SETTING, AND PATIENTS: Endometrium from 4 HLA-mismatched bone marrow transplant recipients (1998-2002) was evaluated for donor HLA expression. Each recipient had a bone marrow donor with an HLA type that enabled determination of the origin of any cell. Endometrial biopsies also were obtained from 4 healthy control women.
MAIN OUTCOME MEASURE: HLA type was determined by immunohistochemistry and by reverse transcription-polymerase chain reaction.
RESULTS: Donor-derived endometrial cells were detected in endometrial biopsy samples from all bone marrow recipients and accounted for 0.2% to 48% of epithelial cells and 0.3% to 52% of stromal cells. None of the controls demonstrated HLA mismatch in endometrial samples.
CONCLUSION: These findings demonstrate that endometrial cells can originate from donor-derived bone marrow cells and suggest that nonuterine stem cells contribute to the regeneration of endometrial tissue.
OBJECTIVE: To investigate the possibility that cells of extrauterine origin could repopulate the endometrium.
DESIGN, SETTING, AND PATIENTS: Endometrium from 4 HLA-mismatched bone marrow transplant recipients (1998-2002) was evaluated for donor HLA expression. Each recipient had a bone marrow donor with an HLA type that enabled determination of the origin of any cell. Endometrial biopsies also were obtained from 4 healthy control women.
MAIN OUTCOME MEASURE: HLA type was determined by immunohistochemistry and by reverse transcription-polymerase chain reaction.
RESULTS: Donor-derived endometrial cells were detected in endometrial biopsy samples from all bone marrow recipients and accounted for 0.2% to 48% of epithelial cells and 0.3% to 52% of stromal cells. None of the controls demonstrated HLA mismatch in endometrial samples.
CONCLUSION: These findings demonstrate that endometrial cells can originate from donor-derived bone marrow cells and suggest that nonuterine stem cells contribute to the regeneration of endometrial tissue.