Antiproliferative action of interferon on murine bone-marrow derived macrophages is influence by the genotype of the marrow-donor.

Mouse interferon inhibits proliferation of bone-marrow derived macrophages. The degree of inhibition of cell proliferation is significant influenced by the genotype of the bone marrow donor in that C57BL/6 cells are more resistant to the cell multiplication inhibitory effect of interferon than are BALB/c cells. These results thus confirm earlier observations using murine erythroid precursors as target cells and point to the existence of genes modulating the action of interferon.