Clinical immunology (Orlando, Fla.) · 2025
Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Zaman Fatima, Zhu Xianming, Hunt Joanne H, Rozek Gracie, Eby Yolanda, Hussain Sarah, Desai Niraj M, Florman Sander, Rana Meenakshi M, Friedman-Moraco Rachel, Pereira Marcus R, Mehta Shikha, Stock Peter, Gilbert Alexander, Hand Jonathan, Morris Michele I, Stosor Valentina, Mehta Sapna A, Small Catherine B, Schaenman Joanna, Santos Carlos A Q, Aslam Saima, Wojciechowski David, Malinis Maricar, Haidar Ghady, Odim Jonah, Morsheimer Megan, Segev Dorry L, Redd Andrew D, Durand Christine M, Tobian Aaron A R
Аннотация
Kidney transplantation from donors with HIV has recently become standard clinical practice, but the plasma inflammatory profile is not well characterized. Thirty-two cytokines and chemokines were evaluated among donors with HIV (n = 63) and without HIV (n = 41). Wilcoxon rank sum test was used to compare cytokines between groups. Donors with and without HIV were generally similar in terms of characteristics, except those with HIV had a non-significantly lower kidney donor profile index, reflecting better graft survival, creatinine, and body mass index. Most cytokine and chemokine levels were similar between groups. However, median IL-8 levels were higher (p < 0.0015) in donors without HIV (32.6 pg/mL, IQR = 13.8-394.9) compared to donors with HIV (15.1 pg/mL, IQR = 8.4-35.5). There were no significant correlations between cytokine and chemokine concentrations and CD4 counts or HIV viral load. In summary, inflammatory profiles were similar or lower among donors with HIV compared to donors without HIV supporting the safety of this emerging kidney transplantation practice.