Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2025
Relationship Between Kidney Donor Profile Index and the Kidney Transplant Function in a Serbian Cohort.
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Kravljaca Milica, Milinkovic Marija, Brkovic Voin, Krivokapic Ivona, Soldatovic Ivan, Radovic Milan, Lausevic Mirjana
Аннотация
OBJECTIVES: Our objective was to investigate the average Kidney Donor Profile Index in the Serbian kidney donor population and its influence on kidney transplant function.
MATERIALS AND METHODS: We conducted a noninterventional retrospective study that included brain dead donors with data between 2010 and 2016. We analyzed the following donor data: sex, age, body mass, body height, race, hypertension and diabetes mellitus, cause of death, terminal creatinine level, hepatitis C positivity, existence of circulatory death before donation, and calculated Kidney Donor Profile Index. We analyzed the following recipient data: sex, age, primary kidney disease, HLA mismatches, cold ischemia time, delayed graft function, acute rejection, surgical complications, and infections after transplant. We used descriptive and analytical statistical methods and used SPSS version 29.0 for all analyses.
RESULTS: Our study included 61 organ donors (27 men and 34 women) of mean age 50.93 ± 13.29 years. The average Kidney Donor Profile Index of our donors was 53.98 ± 27.41%. We did not find that Kidney Donor Profile Index influenced the occurrence of delayed graft function. Kidney transplant recipients who received kidneys with Kidney Donor Profile Index ≤20% had significantly lower serum creatinine level and higher creatinine clearance at 1 year and 3 years after kidney transplant and had lower proteinuria at 1 year posttransplant compared with recipients who received kidneys with higher Kidney Donor Profile Index. Multivariate regression analysis showed that Kidney Donor Profile Index ≤20% was a significant independent predictor of transplanted kidney function at 1 and 3 years posttransplant.
CONCLUSIONS: Kidney Donor Profile Index was significantly associated with allograft function at 1 and 3 years after kidney transplant in our Serbian cohort. Kidney Donor Profile Index ≤20% was shown as an independent predictor of transplanted kidney function.
MATERIALS AND METHODS: We conducted a noninterventional retrospective study that included brain dead donors with data between 2010 and 2016. We analyzed the following donor data: sex, age, body mass, body height, race, hypertension and diabetes mellitus, cause of death, terminal creatinine level, hepatitis C positivity, existence of circulatory death before donation, and calculated Kidney Donor Profile Index. We analyzed the following recipient data: sex, age, primary kidney disease, HLA mismatches, cold ischemia time, delayed graft function, acute rejection, surgical complications, and infections after transplant. We used descriptive and analytical statistical methods and used SPSS version 29.0 for all analyses.
RESULTS: Our study included 61 organ donors (27 men and 34 women) of mean age 50.93 ± 13.29 years. The average Kidney Donor Profile Index of our donors was 53.98 ± 27.41%. We did not find that Kidney Donor Profile Index influenced the occurrence of delayed graft function. Kidney transplant recipients who received kidneys with Kidney Donor Profile Index ≤20% had significantly lower serum creatinine level and higher creatinine clearance at 1 year and 3 years after kidney transplant and had lower proteinuria at 1 year posttransplant compared with recipients who received kidneys with higher Kidney Donor Profile Index. Multivariate regression analysis showed that Kidney Donor Profile Index ≤20% was a significant independent predictor of transplanted kidney function at 1 and 3 years posttransplant.
CONCLUSIONS: Kidney Donor Profile Index was significantly associated with allograft function at 1 and 3 years after kidney transplant in our Serbian cohort. Kidney Donor Profile Index ≤20% was shown as an independent predictor of transplanted kidney function.