Canadian journal of kidney health and disease · 2021
Impact of Perioperative Complications on Living Kidney Donor Health-Related Quality of Life and Mental Health: Results From a Prospective Cohort Study.
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Garcia-Ochoa Carlos, Feldman Liane S, Nguan Chris, Monroy-Caudros Mauricio, Arnold Jennifer B, Barnieh Lianne, Boudville Neil, Cuerden Meaghan S, Dipchand Christine, Gill John S, Karpinski Martin, Klarenbach Scott, Knoll Greg, Lok Charmaine E, Miller Matthew, Prasad G V Ramesh, Sontrop Jessica M, Storsley Leroy, Garg Amit X
Аннотация
BACKGROUND: Although living kidney donation is safe, some donors experience perioperative complications.
OBJECTIVE: This study explored how perioperative complications affected donor-reported health-related quality of life, depression, and anxiety.
DESIGN: This research was a conducted as a prospective cohort study.
SETTING: Twelve transplant centers across Canada.
PATIENTS: A total of 912 living kidney donors were included in this study.
MEASUREMENTS: Short Form 36 health survey, Beck Depression Inventory and Beck Anxiety Inventory.
METHODS: Living kidney donors were prospectively enrolled predonation between 2009 to 2014. Donor perioperative complications were graded using the Clavien-Dindo classification system. Mental and physical health-related quality of life was assessed with the 3 measurements; measurements were taken predonation and at 3- and 12-months postdonation.
RESULTS: Seventy-four donors (8%) experienced a perioperative complication; most were minor (n = 67 [91%]), and all minor complications resolved before hospital discharge. The presence (versus absence) of a perioperative complication was associated with lower mental health-related quality of life and higher depression symptoms 3-month postdonation; neither of these differences persisted at 12-month. Perioperative complications were not associated with any changes in physical health-related quality of life or anxiety 3-month postdonation.
LIMITATIONS: Minor complications may have been missed and information on complications postdischarge were not collected. No minimal clinically significant change has been defined for kidney donors across the 3 measurements.
CONCLUSIONS: These findings highlight a potential opportunity to better support the psychosocial needs of donors who experience perioperative complications in the months following donation.
TRIAL REGISTRATION: NCT00319579 and NCT00936078.
OBJECTIVE: This study explored how perioperative complications affected donor-reported health-related quality of life, depression, and anxiety.
DESIGN: This research was a conducted as a prospective cohort study.
SETTING: Twelve transplant centers across Canada.
PATIENTS: A total of 912 living kidney donors were included in this study.
MEASUREMENTS: Short Form 36 health survey, Beck Depression Inventory and Beck Anxiety Inventory.
METHODS: Living kidney donors were prospectively enrolled predonation between 2009 to 2014. Donor perioperative complications were graded using the Clavien-Dindo classification system. Mental and physical health-related quality of life was assessed with the 3 measurements; measurements were taken predonation and at 3- and 12-months postdonation.
RESULTS: Seventy-four donors (8%) experienced a perioperative complication; most were minor (n = 67 [91%]), and all minor complications resolved before hospital discharge. The presence (versus absence) of a perioperative complication was associated with lower mental health-related quality of life and higher depression symptoms 3-month postdonation; neither of these differences persisted at 12-month. Perioperative complications were not associated with any changes in physical health-related quality of life or anxiety 3-month postdonation.
LIMITATIONS: Minor complications may have been missed and information on complications postdischarge were not collected. No minimal clinically significant change has been defined for kidney donors across the 3 measurements.
CONCLUSIONS: These findings highlight a potential opportunity to better support the psychosocial needs of donors who experience perioperative complications in the months following donation.
TRIAL REGISTRATION: NCT00319579 and NCT00936078.