APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Freedman Barry I, Moxey-Mims Marva M, Alexander Amir A, Astor Brad C, Birdwell Kelly A, Bowden Donald W, Bowen Gordon, Bromberg Jonathan, Craven Timothy E, Dadhania Darshana M, Divers Jasmin, Doshi Mona D, Eidbo Elling, Fornoni Alessia, Gautreaux Michael D, Gbadegesin Rasheed A, Gee Patrick O, Guerra Giselle, Hsu Chi-Yuan, Iltis Ana S, Jefferson Nichole, Julian Bruce A, Klassen David K, Koty Patrick P, Langefeld Carl D, Lentine Krista L, Ma Lijun, Mannon Roslyn B, Menon Madhav C, Mohan Sumit, Moore J Brian, Murphy Barbara, Newell Kenneth A, Odim Jonah, Ortigosa-Goggins Mariella, Palmer Nicholette D, Park Meyeon, Parsa Afshin, Pastan Stephen O, Poggio Emilio D, Rajapakse Nishadi, Reeves-Daniel Amber M, Rosas Sylvia E, Russell Laurie P, Sawinski Deirdre, Smith S Carrie, Spainhour Mitzie, Stratta Robert J, Weir Matthew R, Reboussin David M, Kimmel Paul L, Brennan Daniel C
Аннотация
METHODS: APOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidney donor-recipient pairs and unpaired deceased-donor kidneys.
RESULTS: The United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations, American Society of Transplantation, American Society for Histocompatibility and Immunogenetics, and nearly all U.S. kidney transplant programs, organ procurement organizations (OPOs), and histocompatibility laboratories are participating in this observational study. APOLLO employs a central institutional review board (cIRB) and maintains voluntary partnerships with OPOs and histocompatibility laboratories. A Community Advisory Council composed of African American individuals with a personal or family history of kidney disease has advised the NIH Project Office and Steering Committee since inception. UNOS is providing data for outcome analyses.
CONCLUSION: This article describes unique aspects of the protocol, design, and performance of APOLLO. Results will guide use of APOL1 genotypic data to improve the assessment of quality in deceased-donor kidneys and could increase numbers of transplanted kidneys, reduce rates of discard, and improve the safety of living-kidney donation.