Biomarkers in medicine · 2019
SLPI in the perfusion solution helps to identify graft quality in kidney transplants.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ambrosi Nella G, Caro Fiorella Y, Osella Francisco, Alvarez Leonardo Diaz, Sánchez Francisco, Toniolo Fernanda, Guerrieri Diego, Incardona Claudio, Casadei Domingo, Chuluyan Eduardo
Аннотация
Aim: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results & methodology: The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index <80). Discussion & conclusion: These results suggest that the SLPI concentration in the perfusion solutions could be a predictor of short-term organ function and a complement to the kidney donor profile index score.