Encouraging response of an advanced steroid-cell tumor to GnRH agonist therapy.

BACKGROUND

Chemotherapy for steroid tumors of unspecified type has met with limited success and the overall prognosis has been poor.

CASE: A patient with a virilizing steroid tumor, otherwise unspecified, with demonstrated progressive disease after surgical debulking. Treatment with multiagent chemotherapy failed, but the patient subsequently had a robust response to GnRH agonist therapy.

CONCLUSION

GnRH analogue treatment should be considered prior to cytotoxic chemotherapy in cases of steroid tumor, not otherwise specified.