Hepato-gastroenterology · 2005
Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma.
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Sato Yoshinobu, Yamamoto Satoshi, Oya Hiroshi, Nakatsuka Hideki, Kobayashi Takashi, Takeishi Toshiyuki, Hirano Kenichiro, Hara Yoshiaki, Watanabe Takaoki, Waguri Nobuo, Suda Takeshi, Ichida Takafumi, Aoyagi Yutaka, Hatakeyama Katsuyoshi
Аннотация
BACKGROUND/AIMS: In this study we evaluated the potential role of preoperative h-TERT mRNA expression in peripheral blood as a tool for predicting prognosis and tumor recurrence after living-related liver donor transplantation (LRLDT).
METHODOLOGY: The study included patients with unresectable HCC who underwent LRLDT from July 1999 to May 2003.
RESULTS: There was no significant difference between the survival curves of those patients who met the Milan criteria and those who did not. However, there was a statistically significant difference (p=0.032) between the survival curves of those patients with positive preoperative h-TERT mRNA expression, and those who either had an initially negative preoperative h-TERT mRNA or who converted from positive to negative after neoadjuvant immunochemotherapy.
CONCLUSIONS: In conclusion, the presence or absence of h-TERT mRNA in the peripheral blood may be a useful criterion in evaluating HCC patients for transplantation, as well as a valuable method of assessing anti-tumor therapy and tumor relapse.
METHODOLOGY: The study included patients with unresectable HCC who underwent LRLDT from July 1999 to May 2003.
RESULTS: There was no significant difference between the survival curves of those patients who met the Milan criteria and those who did not. However, there was a statistically significant difference (p=0.032) between the survival curves of those patients with positive preoperative h-TERT mRNA expression, and those who either had an initially negative preoperative h-TERT mRNA or who converted from positive to negative after neoadjuvant immunochemotherapy.
CONCLUSIONS: In conclusion, the presence or absence of h-TERT mRNA in the peripheral blood may be a useful criterion in evaluating HCC patients for transplantation, as well as a valuable method of assessing anti-tumor therapy and tumor relapse.