Journal of clinical practice and research · 2026
The Effect of Myeloid-Derived Suppressor Cells in Graft-versus-Host Disease.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kınaş Burçin Erdem, Doğruel Fatma, Yıldızhan Esra, Beğendi Nermin Keni, Kütük Sinan, Köker Mustafa Yavuz, Çetin Mustafa
Аннотация
OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) are immature myeloid progenitors, including monocytic and granulocytic subgroups (M-MDSCs and PMN-MDSCs). They exhibit immunoregulatory and immunosuppressive properties by limiting immune-mediated pathology and protecting the host from destructive inflammatory damage. Graft-versus-host disease (GVHD) comprises a series of immune-mediated inflammatory events in which donor-derived T cells target the tissues and organs of the transplant recipient. This study aims to evaluate the behavior of MDSCs during GVHD in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
MATERIALS AND METHODS: Fifteen patients who underwent allogeneic HSCT were included in the study. MDSCs and their subsets were identified and characterized by flow cytometry on days 0, 30, 60, and 90 post-engraftment.
RESULTS: The median frequency of monocytic MDSCs (M-MDSCs) on the first day of engraftment was significantly higher in patients without GVHD than in those who developed GVHD. Furthermore, the expansion of M-MDSCs occurred significantly earlier than that of the other MDSC subset.
CONCLUSION: Monocytic MDSCs play a key regulatory role in limiting GVHD and may serve as potential therapeutic targets for GVHD prevention or treatment.
MATERIALS AND METHODS: Fifteen patients who underwent allogeneic HSCT were included in the study. MDSCs and their subsets were identified and characterized by flow cytometry on days 0, 30, 60, and 90 post-engraftment.
RESULTS: The median frequency of monocytic MDSCs (M-MDSCs) on the first day of engraftment was significantly higher in patients without GVHD than in those who developed GVHD. Furthermore, the expansion of M-MDSCs occurred significantly earlier than that of the other MDSC subset.
CONCLUSION: Monocytic MDSCs play a key regulatory role in limiting GVHD and may serve as potential therapeutic targets for GVHD prevention or treatment.