Nature immunology · 2025
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wells Steven B, Rainbow Daniel B, Mark Michal, Szabo Peter A, Ergen Can, Caron Daniel P, Maceiras Ana Raquel, Rahmani Elior, Benuck Eli, Valiollah Pour Amiri Valeh, Chen David, Wagner Allon, Howlett Sarah K, Jarvis Lorna B, Ellis Karen L, Kubota Masaru, Matsumoto Rei, Mahbubani Krishnaa, Saeb-Parsy Kouresh, Conde Cecilia Dominguez, Richardson Laura, Xu Chuan, Li Shuang, Mamanova Lira, Bolt Liam, Wilk Alicja, Teichmann Sarah A, Farber Donna L, Sims Peter A, Jones Joanne L, Yosef Nir
Аннотация
The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from blood and lymphoid and mucosal tissues from 24 organ donors aged 20-75 years. We annotated major lineages (T cells, B cells, innate lymphoid cells and myeloid cells) and corresponding subsets using a multimodal classifier and probabilistic modeling for comparison across tissue sites and age. We identified dominant site-specific effects on immune cell composition and function across lineages; age-associated effects were manifested by site and lineage for macrophages in mucosal sites, B cells in lymphoid organs, and circulating T cells and natural killer cells across blood and tissues. Our results reveal tissue-specific signatures of immune homeostasis throughout the body, from which to define immune pathologies across the human lifespan.