The Journal of infectious diseases · 2025
HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Rozek Gracie M, Yang Ping, Eby Yolanda, Benner Sarah E, Martens Craig, Habtehyimer Feben, Chahoud Maggie, Brown Diane, Desai Niraj M, Florman Sander, Rana Meenakshi M, Pereira Marcus R, Hand Jonathan, Mehta Sapna A, Schaenman Joanna, Santos Carlos A Q, Aslam Saima, Elias Nahel, Odim Jonah, Morsheimer Megan, Segev Dorry L, Durand Christine M, Tobian Aaron A R, Redd Andrew D
Аннотация
Transplantation of kidneys from donors with HIV to recipients with HIV (HIV D+/R+) has been shown to be safe and effective, but there is a unique risk of donor-derived HIV superinfection (HIV-SI) in these recipients. Recipients from a multicenter observational HIV D+/R+ study were examined for HIV-SI by site-directed next-generation sequencing (Illumina). Eighteen recipients of HIV D+/R+ kidney transplants had baseline and follow-up samples that successfully amplified. One recipient was confirmed to have experienced donor-derived HIV-SI at week 26 but did not experience any clinically significant changes. HIV-SI in recipients of HIV D+/R+ transplants is rare, and the clinical ramifications appear negligible.