Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
Organ donation from extracorporeal membrane oxygenation and ventricular assist devices in Victoria, Australia: Characteristics and trends.
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Nainani Viveka K, Arcia Byron, Pilcher David, Ihle Joshua, Diehl Arne, Radford Samuel, D'Costa Rohit, Nanjayya Vinodh B
Аннотация
OBJECTIVE: To describe the characteristics and the trend of organ donation from donors on extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (LVAD).
DESIGN: Retrospective, observational, cohort study from June 2014 to June 2021.
SETTING: A multicentre study in Victoria, Australia, using DonateLife Victoria databases.
PARTICIPANTS: All patients on ECMO/LVAD were referred to DonateLife for organ donation.
MAIN OUTCOME MEASURES: Number, proportion, time trend and type of organ donations from the patients on ECMO/LVAD.
RESULTS: There were 78 donor referrals [mean (SD) age 42 (18.8) yrs, 56 (72 %) males] from patients on Veno-arterial ECMO (73 %), Veno-venous ECMO (16 %) or LVAD (6.4 %), of which 37 (47 %) donated. The annual median (IQR) referral and donation rates were 8 (5-10)/year and 4 (3-7)/year, respectively. Medical contraindications were the main reason for declining organ donation [21(51 %)]. Donation after neurological determination of death (DNDD) occurred in 20 (54 %), and donation after circulatory determination of death (DCDD) in 17 (46 %). The median (IQR) time from admission to referral for donation was longer in DCDD compared to DNDD patients. Eighty-three organs were retrieved from 37 donors (2.24 organs per donor), out of which 68 organs (82 %) were transplanted in 68 recipients. Kidneys were the most common organs retrieved (73 %) and transplanted (79 %).
CONCLUSION: Organ donation on ECMO/LVAD occurs only in half of the referred patients. Further studies are needed to ascertain the barriers to donations and to assess the long-term outcomes of these donations.
DESIGN: Retrospective, observational, cohort study from June 2014 to June 2021.
SETTING: A multicentre study in Victoria, Australia, using DonateLife Victoria databases.
PARTICIPANTS: All patients on ECMO/LVAD were referred to DonateLife for organ donation.
MAIN OUTCOME MEASURES: Number, proportion, time trend and type of organ donations from the patients on ECMO/LVAD.
RESULTS: There were 78 donor referrals [mean (SD) age 42 (18.8) yrs, 56 (72 %) males] from patients on Veno-arterial ECMO (73 %), Veno-venous ECMO (16 %) or LVAD (6.4 %), of which 37 (47 %) donated. The annual median (IQR) referral and donation rates were 8 (5-10)/year and 4 (3-7)/year, respectively. Medical contraindications were the main reason for declining organ donation [21(51 %)]. Donation after neurological determination of death (DNDD) occurred in 20 (54 %), and donation after circulatory determination of death (DCDD) in 17 (46 %). The median (IQR) time from admission to referral for donation was longer in DCDD compared to DNDD patients. Eighty-three organs were retrieved from 37 donors (2.24 organs per donor), out of which 68 organs (82 %) were transplanted in 68 recipients. Kidneys were the most common organs retrieved (73 %) and transplanted (79 %).
CONCLUSION: Organ donation on ECMO/LVAD occurs only in half of the referred patients. Further studies are needed to ascertain the barriers to donations and to assess the long-term outcomes of these donations.