PloS one · 2017
Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Bashir Ali, Attie Oliver, Sullivan Mitchell, Sebra Robert, Singh Kavindra V, Altman Deena, Pak Theodore, Dutta Jayeeta, Chacko Kieran, Webster Elizabeth, Lewis Martha, Hamula Camille, Delli Carpini Kristin W, Murray Barbara E, Kasarskis Andrew, van Bakel Harm, Huprikar Shirish
Аннотация
In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing identified that donor and recipient VRE isolates were highly similar when compared to time-matched hospital isolates. Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches. Given the improved resolution, whole-genome assembly of pathogen genomes is likely to become an essential tool for investigation of potential organ transplant transmissions.