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DOI 10.1093/infdis/jix061

Медицинская библиотека · The Journal of infectious diseases · 2017

Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses.

Jiang Tao, Jiang Jia-Fu, Deng Yong-Qiang, Jiang Bao-Gui, Fan Hang, Han Jian-Feng, Hu Yi, Zhuang Dao-Min, Kargbo David, An Xiao-Ping, Mi Zhi-Qiang, Zhao Guang-Yu, Xin Wen-Wen, Tan Ya-Fang, He Jun, Gao Rong-Bao, Wang Hong, Chen Cao, Wang Feng, Li Chun-Xiao, Zhao Jian-Jun, Cui Yu-Jun, Bei Zhu-Chun, Zhang Ke, Shang Xue-Yi, Zhang Wen-Hui, Pei Guang-Qian, Wang Yun-Fei, Wang Wei, Shu Peng, Liu Wen-Li, Cheng Shi, Zhu Shun-Ya, Kanu Alex, Kargbo Brima, Gao Bo, Tong Yi-Gang, Fang Tong-Yu, Cao Wu-Chun

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Аннотация

We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.

Для цитирования: Jiang Tao, Jiang Jia-Fu, Deng Yong-Qiang, Jiang Bao-Gui, Fan Hang, Han Jian-Feng, Hu Yi, Zhuang Dao-Min, Kargbo David, An Xiao-Ping, Mi Zhi-Qiang, Zhao Guang-Yu, Xin Wen-Wen, Tan Ya-Fang, He Jun, Gao Rong-Bao, Wang Hong, Chen Cao, Wang Feng, Li Chun-Xiao, Zhao Jian-Jun, Cui Yu-Jun, Bei Zhu-Chun, Zhang Ke, Shang Xue-Yi, Zhang Wen-Hui, Pei Guang-Qian, Wang Yun-Fei, Wang Wei, Shu Peng, Liu Wen-Li, Cheng Shi, Zhu Shun-Ya, Kanu Alex, Kargbo Brima, Gao Bo, Tong Yi-Gang, Fang Tong-Yu, Cao Wu-Chun. Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses.. The Journal of infectious diseases. 2017. DOI: 10.1093/infdis/jix061.

Предметные рубрики MeSH

Antibodies, ViralCytokinesDisease OutbreaksEbolavirusGenome, ViralHemorrhagic Fever, EbolaHumansSierra LeoneSurvivorsViral Load
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