Transplantation · 2002
Proteinuria in "normal" cadaver kidney donors.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Steiner Robert, Chanchairujira Thawee, Leyden Sandra
Аннотация
BACKGROUND: More information is needed about cadaver organ donor pathophysiology.
METHODS: We quantitated preprocurement, timed urine protein excretion in 23 "normal" cadaver kidney donors, and correlated results with urine protein dipstick readings and multiple other parameters. We also attempted to measure microalbuminia in 10 subjects.
RESULTS: Seventeen of 23 cadaver donors did not have detectable proteinuria (albuminuria) by urine dipstick testing but had 1,704+/-2,900 mg (mean+/-SD) of quantitated daily urine protein, which did not correlate with creatinine clearance or urine volume. Donors with head trauma had numerically more quantitated proteinuria (3,000+/-5,160 vs. 970+/-670 mg/day, P=0.13). Microalbumin varied from 3 to 34% of the total urine protein concentration.
CONCLUSIONS: Significant proteinuria as measured by quantitative collection techniques is often present in excellent cadaver kidney donors and is not detected by dipstick testing. It may be a marker of important terminal pathophysiologic events and deserves further study.
METHODS: We quantitated preprocurement, timed urine protein excretion in 23 "normal" cadaver kidney donors, and correlated results with urine protein dipstick readings and multiple other parameters. We also attempted to measure microalbuminia in 10 subjects.
RESULTS: Seventeen of 23 cadaver donors did not have detectable proteinuria (albuminuria) by urine dipstick testing but had 1,704+/-2,900 mg (mean+/-SD) of quantitated daily urine protein, which did not correlate with creatinine clearance or urine volume. Donors with head trauma had numerically more quantitated proteinuria (3,000+/-5,160 vs. 970+/-670 mg/day, P=0.13). Microalbumin varied from 3 to 34% of the total urine protein concentration.
CONCLUSIONS: Significant proteinuria as measured by quantitative collection techniques is often present in excellent cadaver kidney donors and is not detected by dipstick testing. It may be a marker of important terminal pathophysiologic events and deserves further study.