PLoS neglected tropical diseases · 2025
Prevalence of Shigellosis among household contacts of index cases in the EFGH catchment area, Dhaka, Bangladesh.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Islam Md Taufiqul, Khanam Farhana, Rajib Md Nazmul Hasan, Hossen Md Ismail, Qudrat-E-Khuda Syed, Ireen Mahzabeen, Firoj Md Golam, Ahmmed Faisal, Biswas Prasanta Kumar, Bhuiyan Amirul Islam, Raz S M Azadul Alam, Mosharraf Md Parvej, Bhuiyan Md Taufiqur Rahman, Qadri Firdausi
Аннотация
BACKGROUND: This study aimed to estimate the prevalence of shigellosis among household contacts (HHCs) using data from the 'Enterics for Global Health (EFGH)' study, conducted at seven Asian and African countries.
METHODS: In Bangladesh, the EFGH study was conducted in Maniknagar, Dhaka, to determine the burden of shigellosis among children aged 6-35 months. HHCs of Shigella-positive patients (index cases) were enrolled in this study. Stool specimens form contacts were collected within 7 days of enrollment of index cases and culture and qPCR were performed. Sociodemographic and behavioral information were obtained to identify risk factors.
RESULTS: A total of 400 HHCs of 118 index cases were enrolled, of which 36 (9%) were positive for Shigella spp. by culture, while qPCR revealed 21% (42/200) of contacts had Shigella infections. Individuals who failed to reheat meals before consumption had a two-fold higher risk of shigellosis compared to those who reheated meals, although other sociodemographic and behavioral factors did not show any significant association.
CONCLUSIONS: The study revealed a high burden of asymptomatic Shigella-infected individuals, emphasizing the need for systematic surveillance to assess the burden and develop effective preventive strategies to prevent the spread of the disease.
METHODS: In Bangladesh, the EFGH study was conducted in Maniknagar, Dhaka, to determine the burden of shigellosis among children aged 6-35 months. HHCs of Shigella-positive patients (index cases) were enrolled in this study. Stool specimens form contacts were collected within 7 days of enrollment of index cases and culture and qPCR were performed. Sociodemographic and behavioral information were obtained to identify risk factors.
RESULTS: A total of 400 HHCs of 118 index cases were enrolled, of which 36 (9%) were positive for Shigella spp. by culture, while qPCR revealed 21% (42/200) of contacts had Shigella infections. Individuals who failed to reheat meals before consumption had a two-fold higher risk of shigellosis compared to those who reheated meals, although other sociodemographic and behavioral factors did not show any significant association.
CONCLUSIONS: The study revealed a high burden of asymptomatic Shigella-infected individuals, emphasizing the need for systematic surveillance to assess the burden and develop effective preventive strategies to prevent the spread of the disease.