Insights into imaging · 2026
Carotid Plaque-RADS improves preoperative coronary risk stratification in candidates for carotid revascularization.
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Qin Rui, Zheng Chong, Zhang Yue, Feng Mengmeng, Zhang Senhao, Gai Qun, Liu Zihang, Li Tong, Wang Ximing, Lu Jie
Аннотация
OBJECTIVES: In this retrospective study, we aimed to assess the predictive value of the Carotid Plaque-RADS (Reporting and Data System) for coronary functional stenosis in candidates for carotid revascularization, using high-resolution magnetic resonance imaging (HR-MRI) coupled with computed tomography-derived fractional flow reserve (CT-FFR).
MATERIALS AND METHODS: A retrospective analysis was performed on data of 101 patients with carotid atherosclerosis who underwent HR-MRI for Carotid Plaque evaluation, and CT-FFR for coronary assessment was conducted. Patients were divided into two groups based on a CT-FFR threshold of ≤ 0.80. Logistic regression, correlation analyses, and receiver operating characteristic curve analyses were used to identify predictors of coronary functional stenosis.
RESULTS: In the functional stenosis group (n = 76), both plaque volume and Carotid Plaque-RADS categories had higher values than those observed in the non-functional group (n = 25). Univariate analysis showed that Carotid Plaque-RADS, Carotid Plaque volume, and hypertension were associated with functional stenosis. After adjustment, Carotid Plaque-RADS remained an independent predictor (odds ratio: 2.35, p < 0.01) and demonstrated the strongest correlation (ρ = 0.51, p < 0.01). It also demonstrated good diagnostic performance (area under the curve [AUC]: 0.81; sensitivity: 85%; specificity: 68%) and favorable clinical utility on decision curve analysis. In an exploratory analysis, Carotid Plaque-RADS was also moderately correlated with CAD-RADS (ρ = 0.37, p < 0.01) and predicted CAD-RADS ≥ 3 with good discrimination (AUC: 0.72).
CONCLUSION: Carotid Plaque-RADS is an independent, noninvasive predictor of coronary functional stenosis in candidates for carotid revascularization.
CRITICAL RELEVANCE STATEMENT: Carotid Plaque-RADS provides a noninvasive imaging-based tool that independently predicts coronary functional stenosis, thereby enhancing preoperative coronary risk stratification and supporting integrated cardiovascular management in candidates for carotid revascularization.
KEY POINTS: Carotid revascularization candidates face high coronary risk. Carotid Plaque-RADS independently predicts coronary functional stenosis. Carotid Plaque-RADS enhances preoperative coronary risk stratification.
MATERIALS AND METHODS: A retrospective analysis was performed on data of 101 patients with carotid atherosclerosis who underwent HR-MRI for Carotid Plaque evaluation, and CT-FFR for coronary assessment was conducted. Patients were divided into two groups based on a CT-FFR threshold of ≤ 0.80. Logistic regression, correlation analyses, and receiver operating characteristic curve analyses were used to identify predictors of coronary functional stenosis.
RESULTS: In the functional stenosis group (n = 76), both plaque volume and Carotid Plaque-RADS categories had higher values than those observed in the non-functional group (n = 25). Univariate analysis showed that Carotid Plaque-RADS, Carotid Plaque volume, and hypertension were associated with functional stenosis. After adjustment, Carotid Plaque-RADS remained an independent predictor (odds ratio: 2.35, p < 0.01) and demonstrated the strongest correlation (ρ = 0.51, p < 0.01). It also demonstrated good diagnostic performance (area under the curve [AUC]: 0.81; sensitivity: 85%; specificity: 68%) and favorable clinical utility on decision curve analysis. In an exploratory analysis, Carotid Plaque-RADS was also moderately correlated with CAD-RADS (ρ = 0.37, p < 0.01) and predicted CAD-RADS ≥ 3 with good discrimination (AUC: 0.72).
CONCLUSION: Carotid Plaque-RADS is an independent, noninvasive predictor of coronary functional stenosis in candidates for carotid revascularization.
CRITICAL RELEVANCE STATEMENT: Carotid Plaque-RADS provides a noninvasive imaging-based tool that independently predicts coronary functional stenosis, thereby enhancing preoperative coronary risk stratification and supporting integrated cardiovascular management in candidates for carotid revascularization.
KEY POINTS: Carotid revascularization candidates face high coronary risk. Carotid Plaque-RADS independently predicts coronary functional stenosis. Carotid Plaque-RADS enhances preoperative coronary risk stratification.