Frontiers in public health · 2026
A 12-month structured exercise reduces epicardial adipose volume in a frequency-dependent manner and lowers serum M-CSF in community-dwelling older adults: a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Xue Xiaojing, Chen Simiao, Cheng Yanling, Li Qiaowei, Ye Zhiqiang, Li Haowen, Huang Feng, Wang Fang
Аннотация
OBJECTIVE: Exercise is a well-established strategy for promoting healthy aging and reducing cardiometabolic risk; however, its effects on epicardial adipose volume (EAV) and associated inflammatory pathways in older adults remain insufficiently understood. This randomized controlled trial examined whether a 12-month structured exercise program reduces EAV in community-dwelling older adults, and secondarily explored changes in serum pro-inflammatory cytokines.
METHODS: This single-center pragmatic randomized controlled trial incorporated a Zelen design. A total of 156 older adults (≥60 years) were evenly allocated to a structured exercise (STE) group or a control group. The control group received health education only; the STE group performed one supervised center-based session plus at least two home-based sessions per week, with matched intensity and duration. EAV, body fat parameters, and circulating pro-inflammatory factors were measured at baseline and after 12 months.
RESULTS: Among the randomized participants, 57 individuals in the control group and 61 individuals in the STE group completed the 12-month follow-up (55 men, 46.6%; mean age 69.17 ± 4.41 years). The absolute EAV change differed significantly between groups (STE vs. control: -15.15 mL, 95% CI -22.61 to -7.69, p < 0.0001). After adjusting for baseline values, only serum macrophage colony-stimulating factor (M-CSF) showed a significant between-group difference (-1.75 pg/mL, 95% CI -3.34 to -0.16, p = 0.032). Univariate linear regression indicated that each additional weekly exercise session was associated with a 3.156 mL greater EAV reduction (R 2 = 0.084).
CONCLUSION: A 12-month structured exercise intervention was associated with reduced EAV and lower circulating M-CSF levels in community-dwelling older adults, with greater reductions observed among participants engaging in more frequent weekly exercise sessions. These findings support regular supervised exercise as a non-pharmacological strategy to reduce cardiac adiposity and modulate inflammation in aging populations.
CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/indexEN.html, ChiCTR2400081824.
METHODS: This single-center pragmatic randomized controlled trial incorporated a Zelen design. A total of 156 older adults (≥60 years) were evenly allocated to a structured exercise (STE) group or a control group. The control group received health education only; the STE group performed one supervised center-based session plus at least two home-based sessions per week, with matched intensity and duration. EAV, body fat parameters, and circulating pro-inflammatory factors were measured at baseline and after 12 months.
RESULTS: Among the randomized participants, 57 individuals in the control group and 61 individuals in the STE group completed the 12-month follow-up (55 men, 46.6%; mean age 69.17 ± 4.41 years). The absolute EAV change differed significantly between groups (STE vs. control: -15.15 mL, 95% CI -22.61 to -7.69, p < 0.0001). After adjusting for baseline values, only serum macrophage colony-stimulating factor (M-CSF) showed a significant between-group difference (-1.75 pg/mL, 95% CI -3.34 to -0.16, p = 0.032). Univariate linear regression indicated that each additional weekly exercise session was associated with a 3.156 mL greater EAV reduction (R 2 = 0.084).
CONCLUSION: A 12-month structured exercise intervention was associated with reduced EAV and lower circulating M-CSF levels in community-dwelling older adults, with greater reductions observed among participants engaging in more frequent weekly exercise sessions. These findings support regular supervised exercise as a non-pharmacological strategy to reduce cardiac adiposity and modulate inflammation in aging populations.
CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/indexEN.html, ChiCTR2400081824.