Frontiers in physiology · 2026
Acute liver failure induced by hepatitis E virus complicated with pancreatitis and refractory acute respiratory distress syndrome after rapid ascent to high altitude: a case report and literature review.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Bowen, Peng Mengjia, Ouyang Junjie, Liu Yangyang, Hong Youjian, Xu Jianguo, Wang Yuliang
Аннотация
BACKGROUND: Acute respiratory distress syndrome (ARDS) and pancreatitis are fatal extrahepatic complication of hepatitis E virus (HEV)-induced acute liver failure (ALF). High-altitude hypobaric hypoxia may exacerbate pulmonary endothelial injury and delay tissue repair, but its impact on the severity and reversibility of ALF-related pancreatitis and ARDS remain uncharacterized.
CASE PRESENTATION: A 44-year-old male (Body mass index 31.7 kg/m2) presented with jaundice, oliguria and progressive hypoxemic respiratory failure 1 month after rapid ascent from 1,190 m to 3,650 m. He was diagnosed with HEV-associated ALF, severe refractory ARDS, stage 3 acute kidney injury (AKI) and concurrent severe acute pancreatitis. Despite lung-protective ventilation, neuromuscular blockade and daily prone positioning, hypoxemia remained refractory at high altitude. The patient also received continuous renal replacement therapy and artificial liver support with dual plasma molecular adsorption system plus double filtration plasmapheresis. After 17 days, his condition stabilized but ARDS and AKI recovery was delayed. Following transfer to a hospital at 500 m altitude, oxygenation, liver and kidney function improved significantly within 3 weeks.
CONCLUSION: Sustained high-altitude hypoxia may contribute to refractoriness and delayed recovery of ALF-related ARDS. Altitude descent may be a valuable adjuvant strategy for hemodynamically stable patients with refractory hypoxemia, pending further prospective validation.
CASE PRESENTATION: A 44-year-old male (Body mass index 31.7 kg/m2) presented with jaundice, oliguria and progressive hypoxemic respiratory failure 1 month after rapid ascent from 1,190 m to 3,650 m. He was diagnosed with HEV-associated ALF, severe refractory ARDS, stage 3 acute kidney injury (AKI) and concurrent severe acute pancreatitis. Despite lung-protective ventilation, neuromuscular blockade and daily prone positioning, hypoxemia remained refractory at high altitude. The patient also received continuous renal replacement therapy and artificial liver support with dual plasma molecular adsorption system plus double filtration plasmapheresis. After 17 days, his condition stabilized but ARDS and AKI recovery was delayed. Following transfer to a hospital at 500 m altitude, oxygenation, liver and kidney function improved significantly within 3 weeks.
CONCLUSION: Sustained high-altitude hypoxia may contribute to refractoriness and delayed recovery of ALF-related ARDS. Altitude descent may be a valuable adjuvant strategy for hemodynamically stable patients with refractory hypoxemia, pending further prospective validation.