bioRxiv : the preprint server for biology · 2026
Multidimensional T 1 - T 2 Relaxation Imaging In Vivo on a Portable 0.064 T MRI Scanner.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
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Wilczynski Ella, Magdoom Kulam Najmudeen, Avram Alexandru V, Williamson Nathan H, Benjamini Dan, Horovitz Silvina G, Basser Peter J
Аннотация
PURPOSE: To demonstrate the feasibility of whole-brain multidimensional T 1 - T 2 relaxation imaging on a portable 0.064 T MRI scanner.
METHODS: A two-dimensional inversion-recovery, fast spin-echo acquisition was used to jointly encode T 1 and T 2 relaxation. Joint relaxation distributions were reconstructed voxel-wise using marginal-distribution constrained optimization (MADCO). The approach was evaluated in a quantitative relaxation MRI phantom and subsequently applied in vivo in a healthy volunteer. Joint distributions, marginal distributions, distribution-derived measures, and statistical dependencies between the two relaxation dimensions were examined.
RESULTS: Phantom joint relaxation estimates showed good overall agreement with mono-exponential relaxation measurements and previously reported values at 0.064 T. The in vivo acquisition provided whole-brain coverage over a broad range of relaxation weightings and tissue contrasts. Reconstructed joint T 1 - T 2 distributions showed spatially organized features across the relaxation space, including broad and overlapping relaxation components that were not fully represented by single-value relaxation maps or by either 1D marginal distribution alone. Selected regions of the joint relaxation space produced component maps with distinct spatial patterns. Statistical analysis further showed a dependence between the two relaxation dimensions, supporting the presence of added information in the joint distribution that is lost when treating T 1 and T 2 separately.
CONCLUSION: Whole-brain multidimensional T 1 - T 2 relaxation imaging is clinically feasible on a portable 0.064 T MRI scanner. Joint relaxation distributions provide information beyond single-value relaxation mapping and may support further developments of quantitative multidimensional imaging at ultra-low field.
METHODS: A two-dimensional inversion-recovery, fast spin-echo acquisition was used to jointly encode T 1 and T 2 relaxation. Joint relaxation distributions were reconstructed voxel-wise using marginal-distribution constrained optimization (MADCO). The approach was evaluated in a quantitative relaxation MRI phantom and subsequently applied in vivo in a healthy volunteer. Joint distributions, marginal distributions, distribution-derived measures, and statistical dependencies between the two relaxation dimensions were examined.
RESULTS: Phantom joint relaxation estimates showed good overall agreement with mono-exponential relaxation measurements and previously reported values at 0.064 T. The in vivo acquisition provided whole-brain coverage over a broad range of relaxation weightings and tissue contrasts. Reconstructed joint T 1 - T 2 distributions showed spatially organized features across the relaxation space, including broad and overlapping relaxation components that were not fully represented by single-value relaxation maps or by either 1D marginal distribution alone. Selected regions of the joint relaxation space produced component maps with distinct spatial patterns. Statistical analysis further showed a dependence between the two relaxation dimensions, supporting the presence of added information in the joint distribution that is lost when treating T 1 and T 2 separately.
CONCLUSION: Whole-brain multidimensional T 1 - T 2 relaxation imaging is clinically feasible on a portable 0.064 T MRI scanner. Joint relaxation distributions provide information beyond single-value relaxation mapping and may support further developments of quantitative multidimensional imaging at ultra-low field.