Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.

In a propensity-matched cohort of adult cardiac or neurosurgical procedures (n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (-0.6%, 95% CI-2.3 to 1.1; p = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation.