Journal of pharmacopuncture · 2026
Effects of Acupuncture at ST36 and SP6 on Activity Levels and Pain Thresholds Through Interleukin-1, Interleukin-6, Cortisol, and Matrix Metalloproteinase-13 Modulation in an Osteoarthritis Rat Model.
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Wulandari Mayang, Handono Kusworini, Khotimah Husnul, Yuliatun Laily
Аннотация
OBJECTIVES: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, inflammation, and altered stress-related responses. This preclinical study examined the effects of acupuncture at ST36 (stomach 36), SP6 (spleen 6), and their combination on pain thresholds, locomotor function, and inflammation and stress-related biomarkers in a monosodium iodoacetate (MIA)-induced OA rat model.
METHODS: Thirty male Wistar rats were randomized into five groups a healthy control, an OA control, and three acupuncture-treated groups (ST36, SP6, and ST36 + SP6). Acupuncture-treated groups underwent eight 15-min sessions of acupuncture per day. Pain thresholds and locomotor activity were assessed before and after treatment. Joint tissue was analyzed for interleukin (IL)-1, IL-6, cortisol, and matrix metalloproteinase-13 (MMP-13) levels. Group differences were analyzed using appropriate parametric or nonparametric tests, and the associations between biomarkers and behavioral outcomes were assessed using Pearson correlation analysis.
RESULTS: The acupuncture-treated rats showed increased pain thresholds (~5.3 g to 9.93-11.60 g, p < 0.05) and higher locomotor activity compared with those in the OA controls. IL-1, IL-6, cortisol, and MMP-13 levels were reduced from pretreatment levels in all acupuncture groups. Biomarker levels were negatively correlated with pain thresholds (r = -0.526 to -0.686) and locomotor activity (r = -0.537 to -0.893; all p < 0.01).
CONCLUSION: In rats with MIA-induced OA, acupuncture was associated with improved pain thresholds and locomotor outcomes and changes in inflammation and stress-related biomarker levels, providing exploratory preclinical evidence linking biomarker modulation with functional responses.
METHODS: Thirty male Wistar rats were randomized into five groups a healthy control, an OA control, and three acupuncture-treated groups (ST36, SP6, and ST36 + SP6). Acupuncture-treated groups underwent eight 15-min sessions of acupuncture per day. Pain thresholds and locomotor activity were assessed before and after treatment. Joint tissue was analyzed for interleukin (IL)-1, IL-6, cortisol, and matrix metalloproteinase-13 (MMP-13) levels. Group differences were analyzed using appropriate parametric or nonparametric tests, and the associations between biomarkers and behavioral outcomes were assessed using Pearson correlation analysis.
RESULTS: The acupuncture-treated rats showed increased pain thresholds (~5.3 g to 9.93-11.60 g, p < 0.05) and higher locomotor activity compared with those in the OA controls. IL-1, IL-6, cortisol, and MMP-13 levels were reduced from pretreatment levels in all acupuncture groups. Biomarker levels were negatively correlated with pain thresholds (r = -0.526 to -0.686) and locomotor activity (r = -0.537 to -0.893; all p < 0.01).
CONCLUSION: In rats with MIA-induced OA, acupuncture was associated with improved pain thresholds and locomotor outcomes and changes in inflammation and stress-related biomarker levels, providing exploratory preclinical evidence linking biomarker modulation with functional responses.