Indian journal of pathology & microbiology · 2026
Osseous metaplasia in neoplastic and non-neoplastic lesions: A comprehensive case series of 30 patients from a tertiary care center.
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Goyal Neeti, Dewan Kritika, Singh Navdeep, Kapoor Umesh, Rana Vandana, Sharma Pragya, Mishra Prabha S, Singh Shamresh, Singhal Paresh, Gupta Arun
Аннотация
BACKGROUND: Osseous metaplasia (OM), distinct from calcification, is a rare histological event reported across various organs in both neoplastic and non-neoplastic contexts, typically as isolated case reports.
OBJECTIVE: This study presents a series of 30 cases of OM from diverse anatomical sites, aiming to broaden the understanding of its pathogenesis and clinical significance.
MATERIAL AND METHODS: A retrospective and prospective histopathological study was conducted over 12 months (August 24 to August 25) in a tertiary care center. Inclusion criteria encompassed all cases of OM confirmed on histology; cases lacking sufficient clinical or tissue data were excluded.
RESULTS: Eighteen cases (19 males, 11 females; age range: 31-74 years) were included. The most frequent sites were the thyroid, kidney, followed by lung, bladder, endometrium, and breast.
CONCLUSION: This is one of the largest single-center series documenting OM across a spectrum of lesions. Recognizing OM can aid in accurate histological interpretation and may have prognostic value in certain tumors.
OBJECTIVE: This study presents a series of 30 cases of OM from diverse anatomical sites, aiming to broaden the understanding of its pathogenesis and clinical significance.
MATERIAL AND METHODS: A retrospective and prospective histopathological study was conducted over 12 months (August 24 to August 25) in a tertiary care center. Inclusion criteria encompassed all cases of OM confirmed on histology; cases lacking sufficient clinical or tissue data were excluded.
RESULTS: Eighteen cases (19 males, 11 females; age range: 31-74 years) were included. The most frequent sites were the thyroid, kidney, followed by lung, bladder, endometrium, and breast.
CONCLUSION: This is one of the largest single-center series documenting OM across a spectrum of lesions. Recognizing OM can aid in accurate histological interpretation and may have prognostic value in certain tumors.