Frontiers in physiology · 2026
Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Varas-Reyes María Carolina, Carrillo-Ávila Bertha Arelly, Martínez-Aguilar Victor, Álvarez-Pérez Marco Antonio, Díaz-Zúñiga Jaime, Melgar-Rodríguez Samanta
Аннотация
BACKGROUND: The traditional healthcare model, focused on symptom management, has shown limitations in addressing chronic diseases. In response, Bioregulatory Systems Medicine (BrSM) has emerged, an approach that promotes the body's self-regulation through multi-component drug and phytotherapeutic treatments. Its potential application in dentistry, particularly in periodontitis, has spurred the study of various natural molecules with the potential to prevent or reduce bone resorption. This qualitative systematic review analyzes the available evidence from animal and human models in the field of bioregulatory periodontal medicine.
METHODS: A qualitative systematic review was conducted according to PRISMA-P guidelines. Animal and human studies published in English or Spanish within the last 10 years were included. The search was performed in five databases (SciELO, CENTRAL, PubMed, LILACS, and Web of Science) using MeSH terms. Data selection and analysis were performed in duplicate. Tools were applied to assess the risk of bias: SYRCLE for animal studies, Newcastle-Ottawa for observational studies, and RoB 2 for randomized controlled trials.
RESULTS: A total of 1,252 articles on calendula, caffeine, piperine, curcumin, and omega-3 fatty acids were found. Fifty-three studies were selected based on inclusion and exclusion criteria. Calendula and piperine reduced bone loss and inflammation in animal models. Curcumin and omega-3 fatty acids showed these effects in both animals and humans. For caffeine, the evidence was contradictory, although antibacterial activity was observed in experimental models.
CONCLUSION: Bioregulatory molecules decrease or prevent bone resorption caused by periodontitis, both in experimental animal studies and in clinical trials in humans.
SYSTEM REVIEW REGISTRATION: https://osf.io/, identifier 3WHNA.
METHODS: A qualitative systematic review was conducted according to PRISMA-P guidelines. Animal and human studies published in English or Spanish within the last 10 years were included. The search was performed in five databases (SciELO, CENTRAL, PubMed, LILACS, and Web of Science) using MeSH terms. Data selection and analysis were performed in duplicate. Tools were applied to assess the risk of bias: SYRCLE for animal studies, Newcastle-Ottawa for observational studies, and RoB 2 for randomized controlled trials.
RESULTS: A total of 1,252 articles on calendula, caffeine, piperine, curcumin, and omega-3 fatty acids were found. Fifty-three studies were selected based on inclusion and exclusion criteria. Calendula and piperine reduced bone loss and inflammation in animal models. Curcumin and omega-3 fatty acids showed these effects in both animals and humans. For caffeine, the evidence was contradictory, although antibacterial activity was observed in experimental models.
CONCLUSION: Bioregulatory molecules decrease or prevent bone resorption caused by periodontitis, both in experimental animal studies and in clinical trials in humans.
SYSTEM REVIEW REGISTRATION: https://osf.io/, identifier 3WHNA.