JACC. Advances · 2025
External Validation of the Veterans Affairs Women Cardiovascular Disease Risk Score to Nonveteran Women.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Jeon-Slaughter Haekyung, Chen Xiaofei, Whyne Erum Z, Tsai Shirling, Barbosa Monica R, Ramanan Bala, Bhushan Sujata, Cao Dian
Аннотация
BACKGROUND: The Veterans Affairs (VA) women cardiovascular disease (CVD) risk score is an internally validated tool to assess the ten-year atherosclerosis CVD (ASCVD) risk in women veterans and has been successfully applied to assess the CVD risk for women veterans.
OBJECTIVES: This study externally validated the VA women CVD risk score to assess the ASCVD risk in civilian women and young active-duty women military service members.
METHODS: This study employed linear calibration models applied to the Cox model stratified by race and ethnicity group, non-Hispanic (N-H) White, N-H Black and Hispanic, and log-likelihood ratio tests in externally validating the VA women CVD risk score for 1,383 civilians (Dallas Heart Study) and 154,168 young active-duty military service members (Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care).
RESULTS: The VA women CVD risk score not only met the good discrimination criterion (C-statistics ≥0.7) but also showed good accuracy in predicting ASCVD events for external populations-Dallas Heart Study civilian women and Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care young active-duty women military service members-across all 3 race and ethnic groups. Calibration in-the-large, a simple update of ASCVD event-free survival, preserved accuracy of the VA women CVD risk score for all races for civilian and young women military service members, except Hispanic civilian women who needed recalibration.
CONCLUSIONS: The calibrated VA women CVD risk score can serve as a validated clinical decision-making tool to screen and assess the CVD risk of nonveteran women-civilian and younger active-duty military service members.
OBJECTIVES: This study externally validated the VA women CVD risk score to assess the ASCVD risk in civilian women and young active-duty women military service members.
METHODS: This study employed linear calibration models applied to the Cox model stratified by race and ethnicity group, non-Hispanic (N-H) White, N-H Black and Hispanic, and log-likelihood ratio tests in externally validating the VA women CVD risk score for 1,383 civilians (Dallas Heart Study) and 154,168 young active-duty military service members (Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care).
RESULTS: The VA women CVD risk score not only met the good discrimination criterion (C-statistics ≥0.7) but also showed good accuracy in predicting ASCVD events for external populations-Dallas Heart Study civilian women and Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care young active-duty women military service members-across all 3 race and ethnic groups. Calibration in-the-large, a simple update of ASCVD event-free survival, preserved accuracy of the VA women CVD risk score for all races for civilian and young women military service members, except Hispanic civilian women who needed recalibration.
CONCLUSIONS: The calibrated VA women CVD risk score can serve as a validated clinical decision-making tool to screen and assess the CVD risk of nonveteran women-civilian and younger active-duty military service members.