Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives.
СтатьяОбзорПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Iwatsubo Takeshi, Sperling Reisa A, Algeciras-Schimnich Alicia, Arai Hidenori, Barron Anna M, Benzinger Tammie L S, Carrillo Maria C, Chen Christopher, Choi Seong Hye, Fontana Igor C, Graff-Radford Jonathan, Grill Joshua D, Heidebrink Judith, Hu Chaur-Jong, Ihara Ryoko, Ikeuchi Takeshi, Iwata Atsushi, Ip Fanny C F, Fitri Fasihah Irfani, Jack Clifford R, Jeong Jee Hyang, Jia Jianping, Kandiah Nagaendran, Kim SangYun, Kowa Hisatomo, La Joie Renaud, Niimi Yoshiki, Noritake Ryoji, Okonkwo Ozioma C, Palmqvist Sebastian, Rafii Michael S, Raman Rema, Shen Yong, Simuni Tanya, Snyder Heather M, Sriwannopas Orapitchaya, Stoeckel Luke E, van der Flier Wiesje M, Wang Huali, Wilcock Donna M, Zetterberg Henrik, Zhou Jin, Mahinrad Simin, Sexton Claire E
Аннотация
The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions-encompassing pharmacological and non-pharmacological strategies-and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. HIGHLIGHTS: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.