American journal of surgery · 2025
Perfused Intestine Gastrografin Study (PIGS) for water bead ingestion small bowel obstructions.
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Pumiglia Luke, Williams Brooklyn, Zhang Bobby Z, Kelly Abi, Riggenbach Zachary, Lutgens Jonathan, Francis Andrew, Prey Beau, Lonneman Molly, Akinmoladun Oladapo O, Van Eaton John, Edinger Allison A, Ciullo Sean, Barlow Meade, Horton John D, Bingham Jason R, Williams James
Аннотация
BACKGROUND: Water beads (WBs) are commonly ingested by children and may expand causing obstruction often requiring surgery. Gastrografin (GG) has been shown to reduce WB diameter ex-vivo and in-vitro. We studied the impact of GG on diameters of WBs in an in-vivo model of porcine bowel.
METHODS: 48 expanded WBs were placed into 45 cm of perfused porcine bowel. Experimental animals (n = 3, 24 WBs) received 50 mL of GG. Controls (n = 3, 24 WBs) received 50 mL of tap water. WBs dwelled for 3 h before extraction.
RESULTS: WBs that dwelled with GG decreased in diameter significantly compared to controls (-30.3 % vs -18 %; p < 0.01). This was conserved on subgroup analyses of 2 sizes of WBs made by 2 manufacturers (-25.35 % vs -10.9 %, p < 0.01; -33.4 % vs -22.6 %, p < 0.01).
CONCLUSION: Gastrografin significantly reduced WB size in a perfused bowel model and may have a role as a non-operative adjunct in managing pediatric WB ingestions.
METHODS: 48 expanded WBs were placed into 45 cm of perfused porcine bowel. Experimental animals (n = 3, 24 WBs) received 50 mL of GG. Controls (n = 3, 24 WBs) received 50 mL of tap water. WBs dwelled for 3 h before extraction.
RESULTS: WBs that dwelled with GG decreased in diameter significantly compared to controls (-30.3 % vs -18 %; p < 0.01). This was conserved on subgroup analyses of 2 sizes of WBs made by 2 manufacturers (-25.35 % vs -10.9 %, p < 0.01; -33.4 % vs -22.6 %, p < 0.01).
CONCLUSION: Gastrografin significantly reduced WB size in a perfused bowel model and may have a role as a non-operative adjunct in managing pediatric WB ingestions.