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DOI 10.1007/s11357-024-01484-7

Медицинская библиотека · GeroScience · 2025

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

Coleman Amanda E, Creevy Kate E, Anderson Rozalyn, Reed May J, Fajt Virginia R, Aicher Kathleen M, Atiee Genna, Barnett Brian G, Baumwart Ryan D, Boudreau Beth, Cunningham Suzanne M, Dunbar Matthew D, Ditzler Bobbie, Ferguson Anna M, Forsyth Kiersten K, Gambino Anya N, Gordon Sonya G, Hammond Hillary K, Holland Sydney N, Iannaccone Mary K, Illing Kate, Kadotani Saki, Knowles Shelby A, MacLean Evan L, Maran Brian A, Markovic Lauren E, McGrath Stephanie, Melvin Rachel L, Mueller Mikaela S, Nelson O Lynne, Olby Natasha J, Pancotto Theresa E, Parsley Elizabeth, Potter Brianna M, Prescott Jena O, Saunders Ashley B, Sawyer Holly M, Scansen Brian A, Schmid Sarah M, Smith Courtney C, Tjostheim Sonja S, Tolbert M Katherine, Tropf Melissa A, Visser Lance C, Ward Jessica L, Wesselowski Sonya R, Windsor Rebecca C, Yang Vicky K, Ruple Audrey, Promislow Daniel E L, Kaeberlein Matt, Dog Aging Project Consortium

Протокол клинического исследованияСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Companion dogs are a powerful model for aging research given their morphologic and genetic variability, risk for age-related disease, and habitation of the human environment. In addition, the shorter life expectancy of dogs compared to human beings provides a unique opportunity for an accelerated timeline to test interventions that might extend healthy lifespan. The Test of Rapamycin In Aging Dogs (TRIAD) randomized clinical trial is a parallel-group, double-masked, randomized, placebo-controlled, multicenter trial that will test the ability of rapamycin to prolong lifespan and improve several healthspan metrics in healthy, middle-aged dogs recruited from Dog Aging Project participants. Here, we describe the rationale, design, and goals of the TRIAD randomized clinical trial, the first rigorous test of a pharmacologic intervention against biological aging with lifespan and healthspan metrics as endpoints to be performed outside of the laboratory in any species.

Для цитирования: Coleman Amanda E, Creevy Kate E, Anderson Rozalyn, Reed May J, Fajt Virginia R, Aicher Kathleen M, Atiee Genna, Barnett Brian G, Baumwart Ryan D, Boudreau Beth, Cunningham Suzanne M, Dunbar Matthew D, Ditzler Bobbie, Ferguson Anna M, Forsyth Kiersten K, Gambino Anya N, Gordon Sonya G, Hammond Hillary K, Holland Sydney N, Iannaccone Mary K, Illing Kate, Kadotani Saki, Knowles Shelby A, MacLean Evan L, Maran Brian A, Markovic Lauren E, McGrath Stephanie, Melvin Rachel L, Mueller Mikaela S, Nelson O Lynne, Olby Natasha J, Pancotto Theresa E, Parsley Elizabeth, Potter Brianna M, Prescott Jena O, Saunders Ashley B, Sawyer Holly M, Scansen Brian A, Schmid Sarah M, Smith Courtney C, Tjostheim Sonja S, Tolbert M Katherine, Tropf Melissa A, Visser Lance C, Ward Jessica L, Wesselowski Sonya R, Windsor Rebecca C, Yang Vicky K, Ruple Audrey, Promislow Daniel E L, Kaeberlein Matt, Dog Aging Project Consortium. Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.. GeroScience. 2025. DOI: 10.1007/s11357-024-01484-7.

Предметные рубрики MeSH

AnimalsDogsFemaleMaleAgingDouble-Blind MethodLongevityMulticenter Studies as TopicProspective StudiesSirolimus
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