American journal of ophthalmology case reports · 2026
Bilateral infection-triggered ligneous conjunctivitis in a 6-month-old patient treated successfully with heparin and allogenic serum eye drops.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Comberg Celia-Louise, Kamga Menes, Masset Maureen, Buelens Tom, Rachdi Majda
Аннотация
PURPOSE: To report a case of successful management of ligneous conjunctivitis (LC) in a pediatric patient.
METHODS: We report the case of a 6-month-old girl presenting with persistent thick membranes on the palpebral conjunctiva after an initial episode of infectious conjunctivitis.
RESULTS: Complete resolution of symptoms was achieved after 4 months of treatment with commercially available heparin-containing artificial tears and allogenic serum drops obtained from maternal blood. Genetic testing later revealed a homozygous pathologic variant of the plasminogen gene (PLG) confirming diagnosis of plasminogen deficiency with associated LC. Clinical remission was sustained 10 months after allogenic serum cessation.
CONCLUSIONS: LC with ocular membrane formation is the most common clinical presentation in patients with type I plasminogen deficiency. The fibrin-rich membranes can lead to sight-threatening complications and reduced quality of life. This is a report of full resolution of ocular membranes in LC after a corticosteroid-sparing treatment combining heparin-containing artificial tears and allogenic serum eye drops in a pediatric patient.
METHODS: We report the case of a 6-month-old girl presenting with persistent thick membranes on the palpebral conjunctiva after an initial episode of infectious conjunctivitis.
RESULTS: Complete resolution of symptoms was achieved after 4 months of treatment with commercially available heparin-containing artificial tears and allogenic serum drops obtained from maternal blood. Genetic testing later revealed a homozygous pathologic variant of the plasminogen gene (PLG) confirming diagnosis of plasminogen deficiency with associated LC. Clinical remission was sustained 10 months after allogenic serum cessation.
CONCLUSIONS: LC with ocular membrane formation is the most common clinical presentation in patients with type I plasminogen deficiency. The fibrin-rich membranes can lead to sight-threatening complications and reduced quality of life. This is a report of full resolution of ocular membranes in LC after a corticosteroid-sparing treatment combining heparin-containing artificial tears and allogenic serum eye drops in a pediatric patient.