ArXiv · 2026
Automated Volumetric Segmentation of Microaneurysms on OCT Using Artificial Intelligence.
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Gao Min, Guo Yukun, Hormel Tristan T, Hao Jinyi, Khan Azaz, Bailey Steven T, Hwang Thomas S, Jia Yali
Аннотация
PURPOSE: To develop and validate a deep learning-based method for the automated identification and volumetric segmentation of microaneurysms (MAs) in diabetic retinopathy (DR) using OCT.
PARTICIPANTS: A total of 125 participants were enrolled, including 20 healthy eyes, 27 with mild NPDR, 30 with moderate NPDR, 30 with severe NPDR, and 18 with PDR.
METHODS: We obtained multiple repeated 3x3-mm scans from each participant using a commercial 120-kHz spectral-domain OCT system (Solix; Visionix/Optovue, Inc., California, USA), which were registered and averaged to generate high-definition volumes. We developed a 3D deep learning network to segment MAs volumetrically. The input to the network consists of the original OCT volume concatenated with its reflectance-inverted counterpart. Expert graders manually delineated MAs to generate annotations. We evaluated model performance at multiple levels, including voxel-level segmentation, lesion-level detection, and eye-level diagnosis.
RESULTS: In the test dataset (20 healthy, 20 DR eyes), the algorithm demonstrated high voxel-level accuracy, with F1 scores of 79.2% on single volumes and 86.1% on averaged volumes. Lesion-level detection reached an F1 score of 96.0% (single) and 97.1% (averaged), while scan-level diagnostic accuracy for MA presence was 97.5% (single and averaged).
CONCLUSIONS: A deep learning-based method can accurately identify and segment MAs volumetrically on OCT, enabling quantification and characterization, and potentially aiding in the diagnosis, monitoring, and management of DR.
PARTICIPANTS: A total of 125 participants were enrolled, including 20 healthy eyes, 27 with mild NPDR, 30 with moderate NPDR, 30 with severe NPDR, and 18 with PDR.
METHODS: We obtained multiple repeated 3x3-mm scans from each participant using a commercial 120-kHz spectral-domain OCT system (Solix; Visionix/Optovue, Inc., California, USA), which were registered and averaged to generate high-definition volumes. We developed a 3D deep learning network to segment MAs volumetrically. The input to the network consists of the original OCT volume concatenated with its reflectance-inverted counterpart. Expert graders manually delineated MAs to generate annotations. We evaluated model performance at multiple levels, including voxel-level segmentation, lesion-level detection, and eye-level diagnosis.
RESULTS: In the test dataset (20 healthy, 20 DR eyes), the algorithm demonstrated high voxel-level accuracy, with F1 scores of 79.2% on single volumes and 86.1% on averaged volumes. Lesion-level detection reached an F1 score of 96.0% (single) and 97.1% (averaged), while scan-level diagnostic accuracy for MA presence was 97.5% (single and averaged).
CONCLUSIONS: A deep learning-based method can accurately identify and segment MAs volumetrically on OCT, enabling quantification and characterization, and potentially aiding in the diagnosis, monitoring, and management of DR.