medRxiv : the preprint server for health sciences · 2026
Bullying, Psychosis-Like Experiences, and Functional Network Connectivity in Adolescents.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Andrés Camazón Pablo, Ballem Ram, Chen Jiayu, Fu Zening, Calhoun Vince, Pearlson Godfrey D, Arango Celso, Díaz-Caneja Covadonga M, Iraji Armin
Аннотация
UNLABELLED: Bullying is an adverse childhood experience affecting up to one-third of the global population and linked to psychosis-like experiences (PLEs), which increase the risk of psychotic disorders. This study aimed to investigate the association between the severity and persistence of bullying and PLEs, including non-paranoid, hallucination-like experiences and their distress, and whether multiscale brain functional network connectivity (msFNC) mediates the pathway from bullying to PLEs.
METHODS: We used data from the ABCD Study, a large, multisite, population-based prospective cohort study following U.S. adolescents. We included adolescents with complete bullying and PLEs assessments at the 2- and 3-year follow-ups (T1: n=10,939, 47% females; T2: n=10,102). We examined the associations between bullying severity and temporal exposure and PLEs using linear mixed-effects models. In a 2-year resting-state fMRI subsample (n=5,280), we used a Neuromark framework to analyze whether msFNC statistically mediated the pathway from bullying to PLEs.
RESULTS: Higher PLEs were associated with the presence and severity of bullying (non-bullied vs. mild bullying: d=-0.24, CI:-0.30 to -0.19, p<0.0001; moderate vs. severe bullying: d=-0.62, CI:-0.69 to -0.56, p<0.0001). When bullying ceased, PLEs returned to non-bullied levels, whereas persistence over two years led to greater elevations (d=-0.36, CI:-0.43 to -0.29, p<0.0001), with similar patterns for non-paranoid and hallucination-like experiences and their distress. msFNC in paralimbic, default-mode, central executive, somatomotor, temporoparietal, insulotemporal, and frontal networks statistically mediated the association.
CONCLUSIONS: Bullying is time- and dose-dependently associated with PLEs. msFNC may provide convergent evidence for distributed neurobiological correlates of the association between bullying exposure and PLEs.
METHODS: We used data from the ABCD Study, a large, multisite, population-based prospective cohort study following U.S. adolescents. We included adolescents with complete bullying and PLEs assessments at the 2- and 3-year follow-ups (T1: n=10,939, 47% females; T2: n=10,102). We examined the associations between bullying severity and temporal exposure and PLEs using linear mixed-effects models. In a 2-year resting-state fMRI subsample (n=5,280), we used a Neuromark framework to analyze whether msFNC statistically mediated the pathway from bullying to PLEs.
RESULTS: Higher PLEs were associated with the presence and severity of bullying (non-bullied vs. mild bullying: d=-0.24, CI:-0.30 to -0.19, p<0.0001; moderate vs. severe bullying: d=-0.62, CI:-0.69 to -0.56, p<0.0001). When bullying ceased, PLEs returned to non-bullied levels, whereas persistence over two years led to greater elevations (d=-0.36, CI:-0.43 to -0.29, p<0.0001), with similar patterns for non-paranoid and hallucination-like experiences and their distress. msFNC in paralimbic, default-mode, central executive, somatomotor, temporoparietal, insulotemporal, and frontal networks statistically mediated the association.
CONCLUSIONS: Bullying is time- and dose-dependently associated with PLEs. msFNC may provide convergent evidence for distributed neurobiological correlates of the association between bullying exposure and PLEs.