Natural product research · 2026
The therapeutic effects and mechanisms of action of baicalin in sepsis: a systematic review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Sayed Usamah, Musa Ali Naji, Jyothi S Renuka, Singh Ritesh, Bainsal Neeraj, Rizaev Jasur, Kholmurodov Inoyatillo
Аннотация
UNLABELLED: Sepsis is a critical medical state considered a life-threatening response to infection, leading to extensive inflammation and potential organ dysfunction. This systematic review focuses on the therapeutic impact of baicalin on sepsis complications.
METHODS: This systematic review followed PRISMA guidelines and was registered in PROSPERO. We searched PubMed, Web of Science, Scopus, Embase, and Google Scholar up to May 10, 2026. We included in vitro and in vivo experimental studies of baicalin in sepsis-related models.
RESULTS: Of 669 records, 41 studies met the eligibility criteria. Baicalin consistently reduced oxidative stress markers, pro-inflammatory cytokines, and activation of NF-κB, TLR4, HMGB1, and NLRP3-related pathways, while increasing antioxidant and anti-inflammatory mediators. Several studies also reported improved organ protection and survival.
CONCLUSIONS: Baicalin appears beneficial in preclinical sepsis models, but evidence certainty is limited by heterogeneity, a lack of human studies, and the absence of a meta-analysis.
METHODS: This systematic review followed PRISMA guidelines and was registered in PROSPERO. We searched PubMed, Web of Science, Scopus, Embase, and Google Scholar up to May 10, 2026. We included in vitro and in vivo experimental studies of baicalin in sepsis-related models.
RESULTS: Of 669 records, 41 studies met the eligibility criteria. Baicalin consistently reduced oxidative stress markers, pro-inflammatory cytokines, and activation of NF-κB, TLR4, HMGB1, and NLRP3-related pathways, while increasing antioxidant and anti-inflammatory mediators. Several studies also reported improved organ protection and survival.
CONCLUSIONS: Baicalin appears beneficial in preclinical sepsis models, but evidence certainty is limited by heterogeneity, a lack of human studies, and the absence of a meta-analysis.