Preventive medicine · 2026
Associations of sleep duration, regularity, efficiency, and genetic susceptibility with incident osteoporosis: A prospective UK biobank study.
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Zheng Zihao, Yang Jiaqi, Wang Yuchen, Dong Peng, Chen Wenzheng, Li Dian, Gao Shanyan, Wei Yingliang
Аннотация
OBJECTIVE: To investigate individual and joint associations of objectively measured sleep duration, regularity, efficiency, and genetic susceptibility with osteoporosis risk.
METHODS: This prospective cohort study used UK Biobank accelerometer data collected in the United Kingdom during 2013-2015. Cox models assessed associations of sleep duration, regularity, and efficiency with osteoporosis risk. A polygenic risk score was constructed to evaluate the joint association of sleep duration, regularity, efficiency, and genetic susceptibility with osteoporosis risk.
RESULTS: Among 63,083 individuals, 1349 osteoporosis cases occurred during a median 7.8-year follow-up. After adjustment, short sleep duration (hazard ratio [HR] = 1.16, 95% confidence interval [CI]: [1.04, 1.31]), irregular sleep (HR = 1.21, 95% CI: [1.02, 1.43]), and low sleep efficiency (HR = 1.23, 95% CI: [1.08, 1.41]) were associated with increased osteoporosis risk. Furthermore, individuals with high genetic susceptibility and short sleep duration (HR = 1.58, 95% CI: [1.23, 2.03]), irregular sleep (HR = 1.86, 95% CI: [1.25, 2.76]), or low sleep efficiency (HR = 1.57, 95% CI: [1.16, 2.13]) had higher osteoporosis risk than those with low genetic susceptibility and normal sleep duration, regular sleep, or high sleep efficiency, respectively.
CONCLUSIONS: Short sleep duration, irregular sleep, and low sleep efficiency were associated with higher osteoporosis risk, including when combined with high genetic susceptibility.
METHODS: This prospective cohort study used UK Biobank accelerometer data collected in the United Kingdom during 2013-2015. Cox models assessed associations of sleep duration, regularity, and efficiency with osteoporosis risk. A polygenic risk score was constructed to evaluate the joint association of sleep duration, regularity, efficiency, and genetic susceptibility with osteoporosis risk.
RESULTS: Among 63,083 individuals, 1349 osteoporosis cases occurred during a median 7.8-year follow-up. After adjustment, short sleep duration (hazard ratio [HR] = 1.16, 95% confidence interval [CI]: [1.04, 1.31]), irregular sleep (HR = 1.21, 95% CI: [1.02, 1.43]), and low sleep efficiency (HR = 1.23, 95% CI: [1.08, 1.41]) were associated with increased osteoporosis risk. Furthermore, individuals with high genetic susceptibility and short sleep duration (HR = 1.58, 95% CI: [1.23, 2.03]), irregular sleep (HR = 1.86, 95% CI: [1.25, 2.76]), or low sleep efficiency (HR = 1.57, 95% CI: [1.16, 2.13]) had higher osteoporosis risk than those with low genetic susceptibility and normal sleep duration, regular sleep, or high sleep efficiency, respectively.
CONCLUSIONS: Short sleep duration, irregular sleep, and low sleep efficiency were associated with higher osteoporosis risk, including when combined with high genetic susceptibility.