Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
The effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Elawady Sameh Samir, Kasem Rahim Abo, Matsukawa Hidetoshi, Cunningham Conor, Sowlat Mohamed Mahdi, Nawabi Noah Lee, Orscelik Atakan, Venegas Joshua M, Isidor Julio, Loulida Hasna, Maier Ilko, Jabbour Pascal, Kim Joon-Tae, Wolfe Stacey Quintero, Rai Ansaar, Starke Robert M, Psychogios Marios-Nikos, Samaniego Edgar A, Goyal Nitin, Yoshimura Shinichi, Cuellar Hugo, Howard Brian, Alawieh Ali, Alaraj Ali, Ezzeldin Mohamad, Romano Daniele G, Tanweer Omar, Mascitelli Justin, Fragata Isabel, Polifka Adam, Siddiqui Fazeel, Osbun Joshua, Grandhi Ramesh, Crosa Roberto, Matouk Charles, Park Min S, Levitt Michael R, Brinjikji Waleed, Moss Mark, Daglioglu Ergun, Williamson Richard, Navia Pedro, Kan Peter, De Leacy Reade, Chowdhry Shakeel, Altschul David J, Spiotta Alejandro M, Al Kasab Sami
Аннотация
BackgroundThe benefit of intravenous thrombolysis (IVT) is well established. We aim to study the benefits of IVT in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) who underwent unsuccessful mechanical thrombectomy (MT).MethodsWe included AIS patients who underwent MT for anterior circulation LVO with failed recanalization (modified treatment in cerebral ischemia [mTICI] score ≤ 2A). Patients who received IVT prior to MT were compared to those who received MT alone. Propensity score matching using demographic, clinical, radiographic and procedural variables was used to match patients with and without IVT. The primary outcome was favorable 90-day good functional outcome (defined as modified Rankin scale of 0-2), and secondary outcomes included intracranial hemorrhage (ICH), symptomatic ICH (sICH), and 90-day mortality.ResultsTotally, 610 AIS patients with unsuccessful MT were included. After propensity matching, 219 patients were identified in each group. Median age was 70 years and 73 years in the IVT + MT and MT alone groups, respectively. In the IVT + MT group, final mTICI scores of 0, 1, and 2A were achieved in 92 (42.0%), 33 (15.1%), and 94 (42.9%) patients, respectively, versus 76 (34.7%), 29 (13.2%), and 114 (52.1%) in the MT alone group. The IVT + MT group had greater odds of 90-day good functional outcome (adjusted odds ratio 2.54, 95% confidence interval 1.53-4.32). There were no significant differences in secondary outcomes.ConclusionsIVT is associated with improved functional outcomes in AIS patients with LVO despite unsuccessful MT.