Expert opinion on biological therapy · 2026
Effectiveness of switching from reference adalimumab to biosimilar adalimumab-atto in patients with chronic non-infectious uveitis.
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Qian Ying, Rodger Damien C, Niu Fang, Delate Thomas, Hui Rita L
Аннотация
INTRODUCTION: Limited real-world studies have evaluated outcomes after switching treatment from a reference product (RP) to a biosimilar product in noninfectious uveitis (NIU). The objective of this real-world study was to assess the outcomes of switching from RP adalimumab to biosimilar adalimumab-atto in the United States.
RESEARCH DESIGN AND METHODS: This retrospective pre-post study included adults with NIU stable on RP adalimumab who were switched to adalimumab-atto and followed for up to six months. Outcomes included the use of systemic and local high-dose corticosteroids, analyzed using interrupted time series analyses, and changes in visual acuity among patients with both pre- and post-switch acuity measurements.
RESULTS: 190 patients were included, with a mean age of 50.5 ± 16.0 years, 61.1% female, and a mean disease duration of 6.5 ± 6.3 years prior to switching. There was no statistically significant trend in usage of either systemic or local high-dose corticosteroid after the switch (p = 0.33 and p = 0.36, respectively). There was no change in vision acuity (n = 110, p = 0.61).
CONCLUSION: The lack of change in systemic or local high-dose corticosteroid use following the switch from RP adalimumab to adalimumab-atto suggests that the switch may be effective and safe in adult patients with NIU.
RESEARCH DESIGN AND METHODS: This retrospective pre-post study included adults with NIU stable on RP adalimumab who were switched to adalimumab-atto and followed for up to six months. Outcomes included the use of systemic and local high-dose corticosteroids, analyzed using interrupted time series analyses, and changes in visual acuity among patients with both pre- and post-switch acuity measurements.
RESULTS: 190 patients were included, with a mean age of 50.5 ± 16.0 years, 61.1% female, and a mean disease duration of 6.5 ± 6.3 years prior to switching. There was no statistically significant trend in usage of either systemic or local high-dose corticosteroid after the switch (p = 0.33 and p = 0.36, respectively). There was no change in vision acuity (n = 110, p = 0.61).
CONCLUSION: The lack of change in systemic or local high-dose corticosteroid use following the switch from RP adalimumab to adalimumab-atto suggests that the switch may be effective and safe in adult patients with NIU.