Infection and drug resistance · 2026
Estimated Glomerular Filtration Rate and Associated Factors Prior to Anti-Tuberculosis Initiation Among Tuberculosis Patients at Bale Zone Hospitals Southeast Ethiopia: A Cross-Sectional Study Design.
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Gezahegn Habtamu, Abebe Gemeda, Bekele Kebebe, Tadesse Samuel, Berhanu Hiwot, Mossie Andualem
Аннотация
BACKGROUND: Tuberculosis is a major public health concern and is mostly associated with systemic complications, like renal impairment. Tuberculosis patients with reduced renal function experience unfavorable outcomes of tuberculosis treatment. In Ethiopia, there are limited studies on glomerular filtration rate. Therefore, early assessment and identification of factors associated with abnormal glomerular filtration rate are paramount for the prevention of renal dysfunction and proper management.
OBJECTIVE: To determine the magnitude of abnormal glomerular filtration rate in patients with tuberculosis before the initiation of anti-tuberculosis therapy.
METHODS: A facility-based cross-sectional study was conducted from July 1 to November 1, 2025. All newly diagnosed adult tuberculosis patients were included from each hospital. Glomerular filtration was determined using the 2021 chronic kidney disease-epidemiology creatinine level equation, and if it is less than 60 mL/min, it is described as a reduced glomerular filtration rate. Descriptive data were reported using frequency tables, graphs, and pie charts. Binary logistic regression analysis with a p-value of < 0.25 was used to select candidates for the multiple logistic regression analysis. Finally, multiple logistic regression analyses were carried out, and a P-value <0.05 were considered as statistically significant.
RESULTS: In this study, 7.99% (23/288) with a 95% confidence interval of 5.13%-11.74% were tuberculosis patients with abnormal glomerular filtration rate. The magnitude of abnormal glomerular filtration rate among tuberculosis patients with anemia was 10.4%. Factors associated with abnormal glomerular filtration rate among patients with tuberculosis before anti-tuberculosis therapy were nausea (AOR=3.4; 1.01-11.1) and cough (AOR=3.3; 1.2-9.2).
CONCLUSION: Abnormal glomerular filtration was higher in patients with tuberculosis and anemia. Anemia can result in a reduction in the glomerular filtration rate due to vasoconstriction of the renal artery, which shifts blood flow to vital organs. Therefore, the renal glomeruli become hypoxic, and their function reduced. Nausea and cough were factors associated with abnormal glomerular filtration rate prior to anti-tuberculosis initiation among tuberculosis patients.
OBJECTIVE: To determine the magnitude of abnormal glomerular filtration rate in patients with tuberculosis before the initiation of anti-tuberculosis therapy.
METHODS: A facility-based cross-sectional study was conducted from July 1 to November 1, 2025. All newly diagnosed adult tuberculosis patients were included from each hospital. Glomerular filtration was determined using the 2021 chronic kidney disease-epidemiology creatinine level equation, and if it is less than 60 mL/min, it is described as a reduced glomerular filtration rate. Descriptive data were reported using frequency tables, graphs, and pie charts. Binary logistic regression analysis with a p-value of < 0.25 was used to select candidates for the multiple logistic regression analysis. Finally, multiple logistic regression analyses were carried out, and a P-value <0.05 were considered as statistically significant.
RESULTS: In this study, 7.99% (23/288) with a 95% confidence interval of 5.13%-11.74% were tuberculosis patients with abnormal glomerular filtration rate. The magnitude of abnormal glomerular filtration rate among tuberculosis patients with anemia was 10.4%. Factors associated with abnormal glomerular filtration rate among patients with tuberculosis before anti-tuberculosis therapy were nausea (AOR=3.4; 1.01-11.1) and cough (AOR=3.3; 1.2-9.2).
CONCLUSION: Abnormal glomerular filtration was higher in patients with tuberculosis and anemia. Anemia can result in a reduction in the glomerular filtration rate due to vasoconstriction of the renal artery, which shifts blood flow to vital organs. Therefore, the renal glomeruli become hypoxic, and their function reduced. Nausea and cough were factors associated with abnormal glomerular filtration rate prior to anti-tuberculosis initiation among tuberculosis patients.