Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications.
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Meutia Alfa Putri, Hidayah Gita Nurul, Moegni Fernandi, Chan Muhammad Syah Nadir, Santoso Budi Iman
Аннотация
BACKGROUND: Vaginal dilators are used to manage genito-pelvic pain/penetration disorder, but longer daily sessions may increase treatment burden. This study evaluated achievement of intercourse and sexual-function outcomes following a multicomponent protocol incorporating 1-min daily vaginal dilation (AM-1 protocol).
METHODS: This retrospective multicentre observational study screened 156 consecutive women with genito-pelvic pain/penetration disorder treated at YPK Mandiri Hospital and Bunda General Hospital, Jakarta, Indonesia, between January 2021 and October 2024. Of these, 123 initiated the AM-1 protocol as sole treatment, and 113 had complete paired pre-treatment and post-treatment Female Sexual Function Index-6 (FSFI-6) data for analysis. The AM-1 protocol combined psychoeducation, pelvic floor relaxation, cognitive reframing and progressive 1-min daily dilation. Outcomes were patient-reported successful unassisted penile-vaginal intercourse and paired FSFI-6 scores assessed at least 4 weeks after successful intercourse.
RESULTS: Successful intercourse was documented in 113 of 123 women who initiated the AM-1 protocol as sole treatment (91.9%; 95% CI 85.6-96.0%); 10 women had no documented follow up and their outcomes were unknown. Among 113 complete cases, median total FSFI-6 score increased from 14 (interquartile range 10-16) before treatment to 22 (IQR 20-26) after treatment, with a median within-participant increase of 10 points (IQR 8-12; P < 0.001). Probable female sexual dysfunction decreased from 100% to 23.9% (P < 0.001).
CONCLUSIONS: In this study, the AM-1 protocol was associated with documented successful intercourse and improved FSFI-6 scores. Comparative studies are needed to determine whether the brief dilation duration improves adherence or outcomes.
METHODS: This retrospective multicentre observational study screened 156 consecutive women with genito-pelvic pain/penetration disorder treated at YPK Mandiri Hospital and Bunda General Hospital, Jakarta, Indonesia, between January 2021 and October 2024. Of these, 123 initiated the AM-1 protocol as sole treatment, and 113 had complete paired pre-treatment and post-treatment Female Sexual Function Index-6 (FSFI-6) data for analysis. The AM-1 protocol combined psychoeducation, pelvic floor relaxation, cognitive reframing and progressive 1-min daily dilation. Outcomes were patient-reported successful unassisted penile-vaginal intercourse and paired FSFI-6 scores assessed at least 4 weeks after successful intercourse.
RESULTS: Successful intercourse was documented in 113 of 123 women who initiated the AM-1 protocol as sole treatment (91.9%; 95% CI 85.6-96.0%); 10 women had no documented follow up and their outcomes were unknown. Among 113 complete cases, median total FSFI-6 score increased from 14 (interquartile range 10-16) before treatment to 22 (IQR 20-26) after treatment, with a median within-participant increase of 10 points (IQR 8-12; P < 0.001). Probable female sexual dysfunction decreased from 100% to 23.9% (P < 0.001).
CONCLUSIONS: In this study, the AM-1 protocol was associated with documented successful intercourse and improved FSFI-6 scores. Comparative studies are needed to determine whether the brief dilation duration improves adherence or outcomes.