Journal of pediatric gastroenterology and nutrition · 2026
Intestinal ultrasound versus magnetic resonance enterography for detecting small bowel Crohn's disease in children.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vos Johanna M B W, Wassenaer Elsa A van, Konert Anouk J, Schuppen Joost van, Rijn Rick R van, Meij Tim G J de, van Limbergen Johan E, Gecse Krisztina B, D'Haens Geert R A M, Benninga Marc A, Koot Bart G P, RAINBOW group
Аннотация
OBJECTIVES: In Crohn's disease (CD), magnetic resonance enterography (MRE) is used to assess small bowel disease activity. Intestinal ultrasound (IUS) is a less invasive, cheaper and more easily accessible imaging modality in CD. This study assesses the diagnostic accuracy of IUS versus MRE and defines an optimal bowel wall thickness (BWT) cut-off in children.
METHODS: Children with CD undergoing MRE as routine care had IUS within 7 days. MRE disease activity was assessed using the segmental grading system and compared to IUS BWT and IUS scores. The terminal ileum (TI), ileum and jejunum were analysed separately.
RESULTS: Seventy-eight paediatric CD patients (median age: 15 years; 49% female) were included. Based on MRE, 44 bowel segments had mild and 37 moderate-severe disease activity. The area under the receiver operating characteristic of IUS BWT for disease activity in the TI was 0.91 (95% confidence interval [CI] 0.84-0.98) with an optimal cut-off of 2.4 mm, 0.80 (95% CI 0.66-0.94) for the ileum with an optimal cut-off of 2.0 mm (sensitivity 76%; specificity 93%) and 0.69 (95% CI 0.52-0.86) for the jejunum. Due to the low number of affected segments in the jejunum, an accurate BWT cut-off value could not be determined. Previously developed IUS scores did not outperform BWT.
CONCLUSIONS: IUS is an accurate tool to non-invasively assess CD activity in the TI and ileum. Based on our results, a BWT cut-off of 2.4 mm in the TI and 2.0 mm in the ileum in paediatric CD is optimal to distinguish active from inactive disease.
METHODS: Children with CD undergoing MRE as routine care had IUS within 7 days. MRE disease activity was assessed using the segmental grading system and compared to IUS BWT and IUS scores. The terminal ileum (TI), ileum and jejunum were analysed separately.
RESULTS: Seventy-eight paediatric CD patients (median age: 15 years; 49% female) were included. Based on MRE, 44 bowel segments had mild and 37 moderate-severe disease activity. The area under the receiver operating characteristic of IUS BWT for disease activity in the TI was 0.91 (95% confidence interval [CI] 0.84-0.98) with an optimal cut-off of 2.4 mm, 0.80 (95% CI 0.66-0.94) for the ileum with an optimal cut-off of 2.0 mm (sensitivity 76%; specificity 93%) and 0.69 (95% CI 0.52-0.86) for the jejunum. Due to the low number of affected segments in the jejunum, an accurate BWT cut-off value could not be determined. Previously developed IUS scores did not outperform BWT.
CONCLUSIONS: IUS is an accurate tool to non-invasively assess CD activity in the TI and ileum. Based on our results, a BWT cut-off of 2.4 mm in the TI and 2.0 mm in the ileum in paediatric CD is optimal to distinguish active from inactive disease.