British journal of anaesthesia · 2026
Cannabis use and anaesthetic agent dosing in patients undergoing surgery or interventional procedures: a single-centre retrospective cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ratajczak Nikolai, Ahrens Elena, Wachtendorf Luca J, Munoz-Acuna Ricardo, Redaelli Simone, Suleiman Aiman, Seibold Eva-Lotte, Hentges Max, Tenge Theresa, von Wedel Dario, Ashrafian Sarah, Paschold Béla-Simon, Chen Guanqing, Hill Kevin P, Schaefer Maximilian S
Аннотация
BACKGROUND: There is limited evidence that habitual cannabis consumption increases anaesthetic requirements. We hypothesised that cannabis use affects anaesthetic dosing among patients undergoing surgery or interventional procedures.
METHODS: A total of 341 199 adult patients undergoing propofol sedation or volatile-based general anaesthesia at Beth Israel Deaconess Medical Center, Boston, USA, between 2008 and 2024 were included. The primary exposure was cannabis use, differentiated into medical or non-medical use (recreational use or cannabis use disorder). Primary outcomes were propofol dose (μg kg-1 min-1) for monitored anaesthesia care and mean end tidal age-adjusted minimum alveolar concentration (MAC) values for general anaesthesia. In multivariable analyses, we estimated the adjusted difference in mean primary anaesthetic agent dosing.
RESULTS: A total of 23 896 patients (7.0%) were identified as non-medical cannabis users, and 3193 (0.9%) held a certification for medical cannabinoids. In adjusted analyses, both non-medical and medical cannabis use were associated with increased propofol doses (non-medical, +6.85 μg kg-1 min-1, 95% CI 6.07-7.63, P<0.001; medical, +2.87 μg kg-1 min-1, 95% CI 0.88-4.86, P=0.005) and doses of volatile anaesthetics (non-medical, +0.01 MAC, 95% CI 0.01-0.02, P<0.001; medical, +0.02 MAC, 95% CI 0.01-0.03, P=0.002). Estimated effects were strongest among frequent users (daily recreational users, +8.41 μg kg-1 min-1 propofol, 95% CI 7.00-9.81, P<0.001). At comparable propofol induction doses, non-medical cannabis users experienced greater heart rate increase after tracheal intubation (+1.45 beats min-1, 95% CI 1.10-1.79, P<0.001).
CONCLUSIONS: Cannabis use was associated with modestly higher propofol and volatile anaesthetic doses. However, effect sizes were smaller than previously reported, and future studies should investigate the clinical relevance.
METHODS: A total of 341 199 adult patients undergoing propofol sedation or volatile-based general anaesthesia at Beth Israel Deaconess Medical Center, Boston, USA, between 2008 and 2024 were included. The primary exposure was cannabis use, differentiated into medical or non-medical use (recreational use or cannabis use disorder). Primary outcomes were propofol dose (μg kg-1 min-1) for monitored anaesthesia care and mean end tidal age-adjusted minimum alveolar concentration (MAC) values for general anaesthesia. In multivariable analyses, we estimated the adjusted difference in mean primary anaesthetic agent dosing.
RESULTS: A total of 23 896 patients (7.0%) were identified as non-medical cannabis users, and 3193 (0.9%) held a certification for medical cannabinoids. In adjusted analyses, both non-medical and medical cannabis use were associated with increased propofol doses (non-medical, +6.85 μg kg-1 min-1, 95% CI 6.07-7.63, P<0.001; medical, +2.87 μg kg-1 min-1, 95% CI 0.88-4.86, P=0.005) and doses of volatile anaesthetics (non-medical, +0.01 MAC, 95% CI 0.01-0.02, P<0.001; medical, +0.02 MAC, 95% CI 0.01-0.03, P=0.002). Estimated effects were strongest among frequent users (daily recreational users, +8.41 μg kg-1 min-1 propofol, 95% CI 7.00-9.81, P<0.001). At comparable propofol induction doses, non-medical cannabis users experienced greater heart rate increase after tracheal intubation (+1.45 beats min-1, 95% CI 1.10-1.79, P<0.001).
CONCLUSIONS: Cannabis use was associated with modestly higher propofol and volatile anaesthetic doses. However, effect sizes were smaller than previously reported, and future studies should investigate the clinical relevance.