Computer methods and programs in biomedicine · 2026
A computational framework for EMG simulation and coherence-based biomarker analysis on neural crosstalk in bimanual coordination.
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Neto Osmar Pinto, Pinho Tatiana O R, Wang Yiyu, Balbinot Gustavo, Kennedy Deanna M
Аннотация
BACKGROUND AND OBJECTIVE: This study presents a computationally and physiologically grounded framework for electromyography (EMG) simulation to examine how assumed cortical and subcortical inputs shape bilateral EMG and intermuscular coherence during bimanual coordination.
METHODS: Simulated first dorsal interosseous (FDI) EMG was generated for a 1:2 force coordination task (approximately 40% maximum voluntary contraction) using motor unit models incorporating (i) variable cortical and subcortical drive weighting, (ii) narrowband versus broadband cortical drive (13-30 vs. 13-60 Hz), and (iii) asymmetric bilateral coupling. Intermuscular EMG-EMG wavelet coherence was computed across α, β, low-γ, and high-γ bands. Model outputs were validated against experimental human EMG at the signal level, comparing simulated and recorded bipolar first dorsal interosseous traces across eight amplitude and frequency-domain signal features.
RESULTS: Coherence magnitude increased with greater modeled neural crosstalk and cortical weighting. The frequency band most sensitive to drive weighting depended on cortical bandwidth: β-band coherence (13-30 Hz) best differentiated cortical and subcortical influences under narrowband drive, whereas low-γ (30-60 Hz) was most informative under broadband conditions. α-band coherence showed minimal sensitivity to subcortical modulation in this context.
CONCLUSIONS: Within this simulation framework, intermuscular coherence was sensitive to modeled bilateral coupling and cortical-subcortical weighting, with diagnostic sensitivity depending on the spectral bandwidth of cortical drive. Thus, the model should be interpreted as a hypothesis generating, signal level framework rather than a direct neural measurement. This open-source framework bridges computational modeling and biomarker signal analysis, supporting reproducible, hypothesis driven biomarker development for neuromotor disorders such as Parkinson's disease, spinal cord injury, and stroke.
METHODS: Simulated first dorsal interosseous (FDI) EMG was generated for a 1:2 force coordination task (approximately 40% maximum voluntary contraction) using motor unit models incorporating (i) variable cortical and subcortical drive weighting, (ii) narrowband versus broadband cortical drive (13-30 vs. 13-60 Hz), and (iii) asymmetric bilateral coupling. Intermuscular EMG-EMG wavelet coherence was computed across α, β, low-γ, and high-γ bands. Model outputs were validated against experimental human EMG at the signal level, comparing simulated and recorded bipolar first dorsal interosseous traces across eight amplitude and frequency-domain signal features.
RESULTS: Coherence magnitude increased with greater modeled neural crosstalk and cortical weighting. The frequency band most sensitive to drive weighting depended on cortical bandwidth: β-band coherence (13-30 Hz) best differentiated cortical and subcortical influences under narrowband drive, whereas low-γ (30-60 Hz) was most informative under broadband conditions. α-band coherence showed minimal sensitivity to subcortical modulation in this context.
CONCLUSIONS: Within this simulation framework, intermuscular coherence was sensitive to modeled bilateral coupling and cortical-subcortical weighting, with diagnostic sensitivity depending on the spectral bandwidth of cortical drive. Thus, the model should be interpreted as a hypothesis generating, signal level framework rather than a direct neural measurement. This open-source framework bridges computational modeling and biomarker signal analysis, supporting reproducible, hypothesis driven biomarker development for neuromotor disorders such as Parkinson's disease, spinal cord injury, and stroke.