Obesity surgery · 2026
Association Between Preoperative Anemia and Incident Chronic Kidney Disease after Metabolic and Bariatric Surgery: a Propensity Score-matched Cohort Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen I-Wen, Kao Chia-Li, Ko Ching-Chung, Lai Yi-Chen, Lin Ming-Chung, Hung Kuo-Chuan
Аннотация
BACKGROUND: Anemia is associated with incident chronic kidney disease (CKD) and is common after metabolic and bariatric surgery (MBS). Given that preoperative anemia may predict postoperative anemia, this study examined whether preoperative anemia was associated with incident CKD following MBS.
METHODS: This propensity score-matched cohort study used data from the TriNetX Research Network. Female patients undergoing laparoscopic sleeve gastrectomy or gastric bypass (2010-2024) were classified by preoperative hemoglobin level (anemia: <12 g/dL; control: ≥12 g/dL). After matching, 7,267 patients remained in each group. The primary outcome was five-year risk of CKD, and secondary outcomes were acute kidney injury (AKI), diabetic kidney complications, and postoperative anemia.
RESULTS: Preoperative anemia was associated with a significantly higher 5-year risk of CKD (hazard ratio[HR] 1.53, 95% confidence interval [CI] 1.16-2.00, P = 0.002), AKI (HR 1.59, 95% CI 1.23-2.06, P < 0.001), and diabetic kidney complications (HR 2.04, 95% CI 1.40-2.98, P < 0.001). Persistent or incident postoperative anemia was markedly more common in the anemia group (HR 2.84, 95% CI 2.71-2.99, P < 0.001), and survival curves showed that intergroup differences appeared earlier for anemia than for CKD. The results remained consistent across sensitivity and subgroup analyses.
CONCLUSION: Preoperative anemia was associated with increased 5-year renal risk after MBS. Postoperative anemia was more frequent among these patients, but this temporal association should not be interpreted as evidence of mediation or causality. Preoperative hemoglobin may help identify patients requiring closer renal surveillance, although further validation is needed.
METHODS: This propensity score-matched cohort study used data from the TriNetX Research Network. Female patients undergoing laparoscopic sleeve gastrectomy or gastric bypass (2010-2024) were classified by preoperative hemoglobin level (anemia: <12 g/dL; control: ≥12 g/dL). After matching, 7,267 patients remained in each group. The primary outcome was five-year risk of CKD, and secondary outcomes were acute kidney injury (AKI), diabetic kidney complications, and postoperative anemia.
RESULTS: Preoperative anemia was associated with a significantly higher 5-year risk of CKD (hazard ratio[HR] 1.53, 95% confidence interval [CI] 1.16-2.00, P = 0.002), AKI (HR 1.59, 95% CI 1.23-2.06, P < 0.001), and diabetic kidney complications (HR 2.04, 95% CI 1.40-2.98, P < 0.001). Persistent or incident postoperative anemia was markedly more common in the anemia group (HR 2.84, 95% CI 2.71-2.99, P < 0.001), and survival curves showed that intergroup differences appeared earlier for anemia than for CKD. The results remained consistent across sensitivity and subgroup analyses.
CONCLUSION: Preoperative anemia was associated with increased 5-year renal risk after MBS. Postoperative anemia was more frequent among these patients, but this temporal association should not be interpreted as evidence of mediation or causality. Preoperative hemoglobin may help identify patients requiring closer renal surveillance, although further validation is needed.