Langenbeck's archives of surgery · 2026
Biophysical rationale and emerging clinical perspectives of surfactants in thoracic surgery: a translational review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yibulayin Xiayimaierdan, Arkin Ehsan, Yang Guangmin, Kalverkamp Sebastian, Spillner Jan W, Greven Johannes
Аннотация
BACKGROUND: Pulmonary surfactants are essential for alveolar stability and gas exchange. While their clinical use is well established in neonatal care, their potential in thoracic surgery remains underexplored.
OBJECTIVE: To review the current and emerging applications of surfactants in thoracic surgical practice, and to assess their role in perioperative lung protection.
METHODS: We reviewed recent literature on surfactant biology, perioperative administration strategies, and novel formulations, including bio-derived and responsive surfactants.
RESULTS: Exogenous surfactants may improve lung compliance, preventing atelectasis, and mitigating postoperative respiratory complications. In thoracic surgery, surfactants may also serve as drug delivery vehicles or anti-inflammatory agents. However, clinical use remains limited, and further studies are needed to define optimal dosing, timing, and patient selection.
CONCLUSIONS: Surfactants represent a versatile and evolving tool in thoracic surgery. With continued innovation and clinical validation, they may become an effective adjunct for enhancing perioperative respiratory outcomes.
OBJECTIVE: To review the current and emerging applications of surfactants in thoracic surgical practice, and to assess their role in perioperative lung protection.
METHODS: We reviewed recent literature on surfactant biology, perioperative administration strategies, and novel formulations, including bio-derived and responsive surfactants.
RESULTS: Exogenous surfactants may improve lung compliance, preventing atelectasis, and mitigating postoperative respiratory complications. In thoracic surgery, surfactants may also serve as drug delivery vehicles or anti-inflammatory agents. However, clinical use remains limited, and further studies are needed to define optimal dosing, timing, and patient selection.
CONCLUSIONS: Surfactants represent a versatile and evolving tool in thoracic surgery. With continued innovation and clinical validation, they may become an effective adjunct for enhancing perioperative respiratory outcomes.