Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
The best type of probiotic for the prevention and treatment of neonatal physiological jaundice: A systematic review and meta-analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Barekatain Behzad, Asefi Zahra, Kelishadi Roya, Yazdi Maryam, Heidari-Beni Motahar
Аннотация
BACKGROUND: Gut microbiota play an important role in bilirubin metabolism and may influence the course of neonatal physiological jaundice. This systematic review and meta-analysis aimed to evaluate the strain-specific efficacy of probiotics in the prevention and adjunctive treatment of neonatal physiological jaundice.
MATERIALS AND METHODS: A comprehensive search of PubMed, Scopus, Embase, Web of Science, Google Scholar, Cochrane Library, World Health Organization databases, and Persian databases (Scientific information database [SID] and Magiran) for studies published up to 2024 was conducted. Randomized controlled trials (RCTs) evaluating probiotics in term and late-preterm neonates (≥35 weeks) with physiological jaundice were included. Data extraction, quality assessment, and meta-analysis were performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines using a random-effects model.
RESULTS: Nineteen RCTs (13 therapeutic and 6 prophylactic) were included. Prophylactic probiotic administration was associated with a reduced need for phototherapy (odds ratio [OR] =0.60; 95% confidence interval [CI]: 0.37-0.96). As an adjunct to phototherapy, probiotics were associated with lower bilirubin levels (mean difference [MD] = -1.61; 95% CI: -3.10--0.11), shorter phototherapy duration (~5 h), and reduced hospitalization (0.3 days). Reduction in bilirubin was more evident during the 2nd and 3rd days of treatment. Strain-specific differences were observed; Clostridium butyricum and Lactobacillus reuteri demonstrated larger pooled effect sizes for bilirubin reduction, whereas Saccharomyces boulardii showed greater protective effect against phototherapy.
CONCLUSION: Probiotics may serve as beneficial adjuncts in the prevention and management of neonatal physiological jaundice, with potential strain-dependent differences. Given heterogeneity and limited data for some strains, findings should be interpreted cautiously. Further well-designed, adequately powered RCTs are warranted.
MATERIALS AND METHODS: A comprehensive search of PubMed, Scopus, Embase, Web of Science, Google Scholar, Cochrane Library, World Health Organization databases, and Persian databases (Scientific information database [SID] and Magiran) for studies published up to 2024 was conducted. Randomized controlled trials (RCTs) evaluating probiotics in term and late-preterm neonates (≥35 weeks) with physiological jaundice were included. Data extraction, quality assessment, and meta-analysis were performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines using a random-effects model.
RESULTS: Nineteen RCTs (13 therapeutic and 6 prophylactic) were included. Prophylactic probiotic administration was associated with a reduced need for phototherapy (odds ratio [OR] =0.60; 95% confidence interval [CI]: 0.37-0.96). As an adjunct to phototherapy, probiotics were associated with lower bilirubin levels (mean difference [MD] = -1.61; 95% CI: -3.10--0.11), shorter phototherapy duration (~5 h), and reduced hospitalization (0.3 days). Reduction in bilirubin was more evident during the 2nd and 3rd days of treatment. Strain-specific differences were observed; Clostridium butyricum and Lactobacillus reuteri demonstrated larger pooled effect sizes for bilirubin reduction, whereas Saccharomyces boulardii showed greater protective effect against phototherapy.
CONCLUSION: Probiotics may serve as beneficial adjuncts in the prevention and management of neonatal physiological jaundice, with potential strain-dependent differences. Given heterogeneity and limited data for some strains, findings should be interpreted cautiously. Further well-designed, adequately powered RCTs are warranted.