Frontiers in neurology · 2026
The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Gong Pengyu, Chen Gang, Chen Shuaiyu, Fei Yaya, Jiang Yuye, Zhang Yiyang, Lu Jiajie, Song Jianhua, Zhang Xiaohao, Zhu Ruixiu, Wang Yuechun
Аннотация
BACKGROUND AND PURPOSE: High-sensitivity C-reactive protein-triglyceride-glucose index (CTI) is an innovative biomarker of insulin resistance and inflammation. The objective of this study was to explore the association of high-sensitivity CTI with functional outcome in elderly patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT).
METHODS: Elderly AIS patients treated with IVT were enrolled in three centers. Unfavorable functional outcome was defined as Modified Rankin Scale score ranging from 3-6. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for the association between high-sensitivity CTI and 3-month functional outcome. Restricted cubic splines (RCS) were performed to explore the shape of this association. Receiver operating characteristic curve was applied to evaluate the discriminatory capacity of high-sensitivity CTI. Furthermore, subgroup and sensitivity analyses were performed to examine the consistency of the observed association.
RESULTS: A total of 708 elderly patients were enrolled, among whom 231 (32.6%) developed unfavorable functional outcome at 3 month follow up. In Model 3, higher continuous high sensitivity CTI levels were independently associated with 3 month unfavorable functional outcome among elderly AIS patients receiving IVT (OR = 1.64; 95% CI, 1.28-2.11). Taking the first quartile of high sensitivity CTI as the reference group, patients in the fourth quartile exhibited the highest risk of unfavorable functional outcome in Model 3 (OR = 2.62, 95% CI, 1.48-4.64). RCS revealed a significant overall association between high sensitivity CTI and unfavorable functional outcome, with no statistically significant nonlinear component (P for overall < 0.001; P for nonlinearity = 0.743). Subgroup and sensitivity analyses demonstrated consistent directions of associations.
CONCLUSION: High-sensitivity CTI was independently associated with functional outcome at 3 months in elderly AIS patients treated with IVT.
METHODS: Elderly AIS patients treated with IVT were enrolled in three centers. Unfavorable functional outcome was defined as Modified Rankin Scale score ranging from 3-6. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for the association between high-sensitivity CTI and 3-month functional outcome. Restricted cubic splines (RCS) were performed to explore the shape of this association. Receiver operating characteristic curve was applied to evaluate the discriminatory capacity of high-sensitivity CTI. Furthermore, subgroup and sensitivity analyses were performed to examine the consistency of the observed association.
RESULTS: A total of 708 elderly patients were enrolled, among whom 231 (32.6%) developed unfavorable functional outcome at 3 month follow up. In Model 3, higher continuous high sensitivity CTI levels were independently associated with 3 month unfavorable functional outcome among elderly AIS patients receiving IVT (OR = 1.64; 95% CI, 1.28-2.11). Taking the first quartile of high sensitivity CTI as the reference group, patients in the fourth quartile exhibited the highest risk of unfavorable functional outcome in Model 3 (OR = 2.62, 95% CI, 1.48-4.64). RCS revealed a significant overall association between high sensitivity CTI and unfavorable functional outcome, with no statistically significant nonlinear component (P for overall < 0.001; P for nonlinearity = 0.743). Subgroup and sensitivity analyses demonstrated consistent directions of associations.
CONCLUSION: High-sensitivity CTI was independently associated with functional outcome at 3 months in elderly AIS patients treated with IVT.