Patient and public involvement (PPI) reporting in maternal and neonatal clinical trials: an exploratory review.

BACKGROUND

Patient and public involvement (PPI) is increasingly a research priority encouraged by health research funders. It is difficult to know, however, how prevalent PPI is within research. The aim of this review was to gain a contemporary understanding of the frequency and types of PPI being reported in maternal and neonatal clinical trial reports, and if an increase in PPI reporting was evident over time.

METHODS

An exploratory review of maternal and neonatal trial reports published in nine healthcare journals between 2017 and 2022 was undertaken. A search was conducted for eligible trial reports in each journal using SCOPUS, in addition to a manual search of each journal's archive. Once an eligible trial report was identified, a search was conducted for the trial's associated protocol. Both trial documents were reviewed for any information on PPI activity. Descriptive statistics of the included trials' characteristics were produced.

RESULTS

Three hundred and fifty-two trial reports, along with the associated trial protocols for 170 trial reports, were identified and included in the analysis. Of these, 48 trials (14%) reported PPI, either within the main trial record (n = 40) or solely in the trial protocol (n = 8). Twenty (42%) of these trials were conducted in the UK. Thirty-six trials reported PPI contributors in trial design and planning, 29 trials reported PPI during the running of the trial, and 20 trials involved contributors in trial analysis and dissemination. There was no sustained increase in PPI reporting over the included timeframe.

CONCLUSIONS

There is minimal reporting of PPI in maternal and neonatal clinical trials, with wide variations in the depth of information provided. PPI reporting guidelines in academic journals may be beneficial in prompting researchers to provide PPI information and to raise awareness of the profile of PPI in maternal and neonatal trial research.

REGISTRATION NUMBER: The review was not registered.