Magnetic resonance in medicine · 2026
Free-Running Three-Dimensional Cardiac Extracellular Volume Mapping in a Single Scan With Mid-Scan Contrast Injection.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lee Wonil, Han Paul Kyu, Marin Thibault, Mounime Ismaël B G, Chi Didi, Bijari Felicitas J, Normandin Marc D, El Fakhri Georges, Ma Chao
Аннотация
PURPOSE: To develop a new method for free-running three-dimensional (3D) extracellular volume mapping of the heart in a single scan with mid-scan contrast injection.
METHODS: 3D cardiac MR imaging was performed with a single scan that acquired k-space data continuously using an inversion recovery (IR) sequence with a spoiled gradient-echo readout. Contrast agent was injected in the middle of the scan. Dynamic images were reconstructed utilizing a linear tangent space alignment (LTSA) model. The pre- and postcontrast T1* was estimated by finding the best fit between the measured signal and the MR signal model, which assumes a linearly time-varying R1* that accounts for T1* changes after the contrast agent injection. Cardiac cine images were synthesized by fitting with the signal model. The 3D ECV mapping was performed using the 3D pre- and postcontrast T1* maps and the measured hematocrit level from blood sampling.
RESULTS: The feasibility of the proposed method was demonstrated through in vivo studies conducted on three healthy subjects using a 3T MR scanner. The ECV maps from the proposed method showed good agreement with those from the MOLLI method. The estimated average myocardial ECV from the proposed and MOLLI methods was 29.82% ± 2.45% and 29.28% ± 2.15%, respectively. The cine images from the proposed method successfully captured the heart's motion. The estimated ejection fraction was 63.3% ± 8%, which was in good agreement with literature values.
CONCLUSION: We developed a novel approach that allows 3D cardiac ECV mapping in a single, free-running, continuous 15-min scan with mid-scan contrast injection.
METHODS: 3D cardiac MR imaging was performed with a single scan that acquired k-space data continuously using an inversion recovery (IR) sequence with a spoiled gradient-echo readout. Contrast agent was injected in the middle of the scan. Dynamic images were reconstructed utilizing a linear tangent space alignment (LTSA) model. The pre- and postcontrast T1* was estimated by finding the best fit between the measured signal and the MR signal model, which assumes a linearly time-varying R1* that accounts for T1* changes after the contrast agent injection. Cardiac cine images were synthesized by fitting with the signal model. The 3D ECV mapping was performed using the 3D pre- and postcontrast T1* maps and the measured hematocrit level from blood sampling.
RESULTS: The feasibility of the proposed method was demonstrated through in vivo studies conducted on three healthy subjects using a 3T MR scanner. The ECV maps from the proposed method showed good agreement with those from the MOLLI method. The estimated average myocardial ECV from the proposed and MOLLI methods was 29.82% ± 2.45% and 29.28% ± 2.15%, respectively. The cine images from the proposed method successfully captured the heart's motion. The estimated ejection fraction was 63.3% ± 8%, which was in good agreement with literature values.
CONCLUSION: We developed a novel approach that allows 3D cardiac ECV mapping in a single, free-running, continuous 15-min scan with mid-scan contrast injection.