A Proof-of-Concept Spike Based Neuromorphic Brain-Computer Interface.

Closed-loop brain-computer interfaces (BCIs) hold promise for restoring function after neurological damage by dynamically processing neural signals and delivering targeted brain stimulation. To achieve clinically meaningful outcomes, such systems must operate with high spatiotemporal precision. This work aims to demonstrate a proof-of-concept neuromorphic BCI that processes neural spike events in near-real time, without necessitating preprocessing besides signal filtering and spike detection. Methods - We developed a system that acquires neural signals and streams spike events into a spiking neural network (SNN) running on SpiNNaker neuromorphic hardware. We evaluated the system's performance using both in vivo recordings from mouse visual cortex and simulated neural waveforms. We measured the roundtrip latency, defined as the time from spike detection to an output spike generated by the SNN. Results - Under baseline conditions with no hidden SNN layers, mean roundtrip latency was 4.69 ms (±1.70 ms). Adding hidden layers increased latency by approximately 3.65 ms per layer, reflecting the computational overhead of deeper networks. The system successfully detected and processed spikes in near real-time, demonstrating that neuromorphic hardware can manage spike-based input at speeds suitable for closed-loop intervention. Discussion - These findings indicate that neuromorphic SNNs can rapidly process neural signals, providing a foundation for closed-loop BCIs capable of bypassing damaged neural pathways. Future efforts will involve implementing stimulation protocols and functional SNNs. Such developments may ultimately facilitate more effective, flexible, and power-efficient neuroprosthetic devices.